儿茶酚-O-甲基转移酶（COMT）Val158Met多态性与饮食失调：来自一个新生物样本库的数据及对既往发表研究的荟萃分析
Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies.
作者信息
Collantoni Enrico, Solmi Marco, Gallicchio Davide, Santonastaso Paolo, Meneguzzo Paolo, Carvalho Andrè F, Stubbs Brendon, Clementi Maurizio, Pinato Claudia, Forzan Monica, Cassina Matteo, Fontana Francesca, Piva Ivana, Siani Roberta, Salvo Pierandrea, Tenconi Elena, Veronese Nicola, Correll Christoph U, Favaro Angela
机构信息
Neuroscience Department, University of Padua, Italy.
BIO.VEDA Group (Biobanca Veneta per i Disturbi dell'Alimentazione: Biobank of the Veneto Region Eating Disorders Units), Italy.
出版信息
Eur Eat Disord Rev. 2017 Nov;25(6):524-532. doi: 10.1002/erv.2555.
OBJECTIVES
We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs).
METHODS
We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian 'Biobanca Veneta per i Disturbi Alimentari' biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls.
RESULTS
Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96-1.04, p-values: 0.46-0.97, I = 0%] and when analysing separately patients with AN (ORs: 0.94-1.04, p-values: 0.31-0.61, I = 0%) or BN (ORs: 0.80-1.09, p-values: 0.28-0.64, I = 0-44%).
CONCLUSIONS
Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
目的
我们研究了儿茶酚-O-甲基转移酶（COMT）Val158Met基因多态性是否与饮食失调（EDs）相关。
方法
我们对截至2017年1月15日发表的研究进行了系统的文献检索，并纳入了意大利“饮食失调生物银行（Biobanca Veneta per i Disturbi Alimentari）”的数据，进行荟萃分析，比较饮食失调患者与神经性厌食症（AN）或神经性贪食症（BN）患者以及对照组中COMT Val158Met基因型和等位基因频率。
结果
纳入了10项研究以及饮食失调生物银行的数据（饮食失调患者：n = 920，对照组：n = 261），其中包括3541例饮食失调患者（神经性厌食症患者 = 2388例；神经性贪食症患者 = 233例）和3684例对照组。对于合并的所有饮食失调患者，以及分别分析神经性厌食症患者（比值比范围：0.94 - 1.04，p值：0.31 - 0.61，I² = 0%）或神经性贪食症患者（比值比范围：0.80 - 1.09，p值：0.28 - 0.64，I² = 0 - 44%）时，患者与对照组之间的COMT Val158Met等位基因和基因型频率均无显著组间差异。
结论
对11项研究和7225名受试者的数据进行荟萃分析表明，COMT Val158Met基因多态性与饮食失调无关。版权所有© 2017 John Wiley & Sons, Ltd和饮食失调协会。
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