a Department of Otorhinolaryngology, Head and Neck Surgery and Audiology , Rigshospitalet University of Copenhagen , Copenhagen , Denmark.
b Department of Pathology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.
Acta Oncol. 2018 Feb;57(2):269-275. doi: 10.1080/0284186X.2017.1390251. Epub 2017 Oct 23.
Oropharyngeal carcinomas (OPCs) constitute a significant and increasing proportion of head and neck carcinomas and are an important global cause of morbidity and mortality. The purpose of this study was to determine trends in incidence and survival in OPC in the Danish population from 1980 to 2014.
This study included all patients registered in the nationwide Danish Cancer Registry over the period 1980-2014. The age-adjusted incidence rates (AAIR) per 100,000, annual percentage change (APC) and average annual percent change (AAPC) were evaluated. Five-year relative survival (RS) was calculated with Cox regression analyses in relation to gender, anatomical location and histology.
A total of 6555 patients (69% male) were included, with a median age at diagnosis of 60 years. The AAIR of patients with OPC increased from 0.815 per 100,000 in 1980 to 4.51 per 100,000 in 2014 with an AAPC of 5.3. The 5-year RS increased significantly from 33.1% over the period 1980-1984 to 58.5% (25.4% points) over the period 2010-2014. With no significant difference stratified for gender. Tumors located at the palatine tonsils (n = 3333) and salivary gland OPC (n = 90) had significantly better survival compared with other sub-locations and histology subtypes. In the APC model the birth cohort effect rate ratio increased until 1925 and then decreased until 1935 from which point it increased in the last cohorts.
In this population-based study, we observed a significant increase in the incidence of OPCs and in the RS for OPC. We also identified a profound birth cohort effect on the incidence.
口咽癌（OPC）构成了头颈部癌的重要且不断增加的比例，是全球发病率和死亡率的重要原因。本研究的目的是确定 1980 年至 2014 年丹麦人群中 OPC 的发病率和生存率趋势。
本研究包括在 1980-2014 年期间在全国性丹麦癌症登记处登记的所有患者。评估了每 100,000 人的年龄调整发病率（AAIR）、年百分比变化（APC）和平均年百分比变化（AAPC）。使用 Cox 回归分析评估了与性别、解剖位置和组织学相关的 5 年相对生存率（RS）。
共纳入 6555 例患者（69%为男性），中位诊断年龄为 60 岁。OPC 患者的 AAIR 从 1980 年的 0.815/100,000 增加到 2014 年的 4.51/100,000，AAPC 为 5.3。1980-1984 年期间的 5 年 RS 从 33.1%显著增加到 2010-2014 年期间的 58.5%（25.4 个百分点）。性别分层无显著差异。位于腭扁桃体（n=3333）和唾液腺癌（n=90）的肿瘤与其他亚部位和组织学亚型相比，生存率显著提高。在 APC 模型中，出生队列效应比率增加，直到 1925 年，然后从 1935 年开始下降，此后最后几个队列中再次增加。
在这项基于人群的研究中，我们观察到 OPC 的发病率和 OPC 的 RS 显著增加。我们还发现发病率存在深刻的出生队列效应。
