Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Denmark.
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Denmark.
Oral Oncol. 2021 Nov;122:105583. doi: 10.1016/j.oraloncology.2021.105583. Epub 2021 Oct 22.
Nasopharyngeal malignancies are reported having decreasing incidence and reduced mortality. This study provides a nationwide update of the incidence and survival in Denmark.
The Danish Cancer Registry (DCR) and Central Population Register (CPR) were used to identify all patients registered with nasopharyngeal malignancies between 1980 and 2014 in Denmark. We evaluated the age-adjusted incidence rate (AAIR), average annual percent change (AAPC) and relative survival (RS) and also constructed age-population-cohort (APC) models.
911 patients were identified with a male:female ratio of 2.2:1, a median age of 57.7 years (range 2.8-98.3 years) and an overall median follow-up time of 2.7 years (range 0-37 years). The AAIR was 0.39 cases per 100 000 in 1980 and 0.28 cases per 100 000 in 2014 with an AAPC of -3.2 (95% CI: -7.5; 1.2, p = 0.1). The overall 1-year and 5-year RS rates were 76.3% and 42.1%, respectively. We found a significant age effect in the APC model for the incidence of nasopharyngeal malignancies, but no significant cohort or period effects.
The incidence of nasopharyngeal carcinomas has slightly decreased over the last four decades, however insignificantly. Meanwhile, the relative survival has increased significantly in Denmark since 1980. The cause of improved relative survival might be attributed to altered treatment practices.
据报道，鼻咽癌的发病率正在下降，死亡率也在降低。本研究提供了丹麦全国范围内鼻咽癌发病率和生存率的最新数据。
使用丹麦癌症登记处（DCR）和中央人口登记处（CPR），在丹麦确定了 1980 年至 2014 年间所有患有鼻咽癌的患者。我们评估了年龄调整发病率（AAIR）、平均年百分比变化（AAPC）和相对生存率（RS），并构建了年龄-人群-队列（APC）模型。
共确定了 911 名患者，男女性别比为 2.2:1，中位年龄为 57.7 岁（范围为 2.8-98.3 岁），总体中位随访时间为 2.7 年（范围为 0-37 年）。1980 年的 AAIR 为 0.39 例/100,000，2014 年为 0.28 例/100,000，AAPC 为-3.2（95%CI：-7.5；1.2，p=0.1）。总的 1 年和 5 年 RS 率分别为 76.3%和 42.1%。我们发现 APC 模型中鼻咽癌的发病率存在显著的年龄效应，但没有显著的队列或时期效应。
在过去的四十年中，鼻咽癌的发病率略有下降，但不显著。同时，自 1980 年以来，丹麦的相对生存率显著提高。相对生存率提高的原因可能归因于治疗实践的改变。
