Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China.
Department of Burns, Rui Jin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Sci Rep. 2017 Oct 20;7(1):13720. doi: 10.1038/s41598-017-13151-3.
Red blood cell distribution width (RDW), platelet count (PLT), and a RDW-to-PLT ratio (RPR) have been associated with inflammatory activity and adverse outcomes in many diseases. This study has aimed to investigate the association between these indicators and the mortality rate of severe burn patients. From 2008 to 2014, 610 cases of severe burn patients from two burn centers in eastern China were enrolled in this study. Eighty-eight patients died within 90 days after admission. The RDW, PLT, and RPR were studied through Cox regression analysis on the 3rd and 7th day. The RDW, PLT, and RPR values on the 3rd and 7th day were significantly associated with the outcomes of severe burn patients (P < 0.01). High RPR was significantly associated with a 90-day mortality rate at the two time points. However, the RDW and PLT did not provide independent predictive values. Our results indicated that the RPR values on the 3rd and 7th day were associated with the mortality rates of severe burn patients (P < 0.01). Meanwhile, the RDW and PLT values at these time points failed to provide independent values for burn mortality prediction. Thus, the RPR can serve as an independent and novel marker for mortality rates prediction in severe burn patients.
红细胞分布宽度（RDW）、血小板计数（PLT）和 RDW 与 PLT 的比值（RPR）与许多疾病的炎症活动和不良结局有关。本研究旨在探讨这些指标与严重烧伤患者死亡率之间的关系。2008 年至 2014 年，本研究纳入了来自中国东部两个烧伤中心的 610 例严重烧伤患者。88 例患者在入院后 90 天内死亡。通过 Cox 回归分析，在第 3 天和第 7 天研究了 RDW、PLT 和 RPR。第 3 天和第 7 天的 RDW、PLT 和 RPR 值与严重烧伤患者的预后显著相关（P<0.01）。高 RPR 在两个时间点均与 90 天死亡率显著相关。然而，RDW 和 PLT 并未提供独立的预测值。我们的结果表明，第 3 天和第 7 天的 RPR 值与严重烧伤患者的死亡率相关（P<0.01）。同时，这些时间点的 RDW 和 PLT 值未能为烧伤死亡率预测提供独立值。因此，RPR 可作为严重烧伤患者死亡率预测的独立和新型标志物。
