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Revisiting GM-CSF as an adjuvant for therapeutic vaccines.重新审视粒细胞-巨噬细胞集落刺激因子作为治疗性疫苗的佐剂
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2
Overcoming HBV immune tolerance to eliminate HBsAg-positive hepatocytes via pre-administration of GM-CSF as a novel adjuvant for a hepatitis B vaccine in HBV transgenic mice.通过预先给予粒细胞巨噬细胞集落刺激因子（GM-CSF）作为乙型肝炎疫苗的新型佐剂来克服HBV免疫耐受，以消除HBsAg阳性肝细胞，该研究在HBV转基因小鼠中进行。
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Efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) as a vaccine adjuvant for hepatitis B virus in patients with HIV infection.粒细胞巨噬细胞集落刺激因子（GM-CSF）作为乙型肝炎病毒疫苗佐剂在HIV感染患者中的疗效。
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Effects of granulocyte-macrophage colony-stimulating factor and foreign helper protein as immunologic adjuvants on the T-cell response to vaccination with tyrosinase peptides.粒细胞巨噬细胞集落刺激因子和外来辅助蛋白作为免疫佐剂对酪氨酸酶肽疫苗接种后T细胞反应的影响
Int J Cancer. 2003 Mar 20;104(2):188-94. doi: 10.1002/ijc.10961.
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Injection of DNA encoding granulocyte-macrophage colony-stimulating factor recruits dendritic cells for immune adjuvant effects.注射编码粒细胞-巨噬细胞集落刺激因子的DNA可募集树突状细胞以产生免疫佐剂效应。
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Differential immunostimulating effect of granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF) and interferon gamma (IFNgamma) after severe trauma.严重创伤后粒细胞-巨噬细胞集落刺激因子（GM-CSF）、粒细胞集落刺激因子（G-CSF）和干扰素γ（IFNγ）的差异免疫刺激作用
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Granulocyte-macrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice.粒细胞-巨噬细胞集落刺激因子和干扰素-γ可恢复脂多糖脱敏小鼠对内毒素的全身性肿瘤坏死因子-α反应。
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[The adjuvant effect of granulocyte macrophage colony stimulating factor (GM-CSF) in dengue virus and hepatitis C virus DNA vaccines].[粒细胞巨噬细胞集落刺激因子（GM-CSF）在登革病毒和丙型肝炎病毒DNA疫苗中的佐剂作用]
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Granulocyte macrophage colony-stimulating factor as an adjuvant for hepatitis B vaccination: a meta-analysis.粒细胞巨噬细胞集落刺激因子作为乙型肝炎疫苗的佐剂：一项荟萃分析。
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Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response.用同基因的、淋巴瘤衍生的免疫球蛋白独特型与粒细胞/巨噬细胞集落刺激因子联合接种疫苗，可使小鼠产生保护性T细胞应答。
Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10972-7. doi: 10.1073/pnas.93.20.10972.

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Bioeng Transl Med. 2023 Aug 21;8(6):e10591. doi: 10.1002/btm2.10591. eCollection 2023 Nov.
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Cancers (Basel). 2023 Aug 4;15(15):3978. doi: 10.3390/cancers15153978.
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Engineering a versatile and retrievable cell macroencapsulation device for the delivery of therapeutic proteins.设计一种用于递送治疗性蛋白质的多功能且可回收的细胞宏观封装装置。
iScience. 2023 Jul 13;26(8):107372. doi: 10.1016/j.isci.2023.107372. eCollection 2023 Aug 18.
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Modular Hydrogel Vaccine for Programmable and Coordinate Elicitation of Cancer Immunotherapy.模块化水凝胶疫苗用于可编程和协调的癌症免疫治疗。
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Advanced immunotherapies for glioblastoma: tumor neoantigen vaccines in combination with immunomodulators.高级免疫疗法治疗胶质母细胞瘤：肿瘤新抗原疫苗联合免疫调节剂。
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Neoantigen Vaccines; Clinical Trials, Classes, Indications, Adjuvants and Combinatorial Treatments.新抗原疫苗；临床试验、类别、适应症、佐剂及联合治疗
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O-glycosylation and its role in therapeutic proteins.O-糖基化及其在治疗性蛋白质中的作用。
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本文引用的文献

1
Enrichment of Ly6C monocytes by multiple GM-CSF injections with HBV vaccine contributes to viral clearance in a HBV mouse model.多次注射 GM-CSF 联合乙肝疫苗可使 Ly6C 单核细胞富集，有助于清除乙肝病毒小鼠模型中的病毒。
Hum Vaccin Immunother. 2017 Dec 2;13(12):2872-2882. doi: 10.1080/21645515.2017.1344797. Epub 2017 Jul 12.
2
Overcoming HBV immune tolerance to eliminate HBsAg-positive hepatocytes via pre-administration of GM-CSF as a novel adjuvant for a hepatitis B vaccine in HBV transgenic mice.通过预先给予粒细胞巨噬细胞集落刺激因子（GM-CSF）作为乙型肝炎疫苗的新型佐剂来克服HBV免疫耐受，以消除HBsAg阳性肝细胞，该研究在HBV转基因小鼠中进行。
Cell Mol Immunol. 2016 Nov;13(6):850-861. doi: 10.1038/cmi.2015.64. Epub 2015 Jul 13.
3
New generation adjuvants--from empiricism to rational design.新一代佐剂——从经验主义到理性设计
Vaccine. 2015 Jun 8;33 Suppl 2:B14-20. doi: 10.1016/j.vaccine.2015.01.088.
4
Severe adverse immunologic reaction in a patient with glioblastoma receiving autologous dendritic cell vaccines combined with GM-CSF and dose-intensified temozolomide.胶质母细胞瘤患者在接受自体树突状细胞疫苗联合 GM-CSF 和剂量强化替莫唑胺治疗时发生严重免疫不良反应。
Cancer Immunol Res. 2015 Apr;3(4):320-5. doi: 10.1158/2326-6066.CIR-14-0100. Epub 2014 Nov 11.
5
A feasibility study of cyclophosphamide, trastuzumab, and an allogeneic GM-CSF-secreting breast tumor vaccine for HER2+ metastatic breast cancer.环磷酰胺、曲妥珠单抗和同种异体 GM-CSF 分泌的乳腺癌肿瘤疫苗治疗 HER2+转移性乳腺癌的可行性研究。
Cancer Immunol Res. 2014 Oct;2(10):949-61. doi: 10.1158/2326-6066.CIR-14-0058. Epub 2014 Aug 12.
6
The granulocyte macrophage-colony stimulating factor surface modified MB49 bladder cancer stem cells vaccine against metastatic bladder cancer.粒细胞巨噬细胞集落刺激因子表面修饰的MB49膀胱癌干细胞疫苗用于治疗转移性膀胱癌。
Stem Cell Res. 2014 Jul;13(1):111-22. doi: 10.1016/j.scr.2014.04.006. Epub 2014 Apr 24.
7
Phase I trial of Wilms' Tumor 1 (WT1) peptide vaccine with GM-CSF or CpG in patients with solid malignancy.WT1 肽疫苗联合 GM-CSF 或 CpG 在实体恶性肿瘤患者中的 I 期临床试验。
Anticancer Res. 2012 Jun;32(6):2263-9.
8
Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy.GM-CSF 对树突状细胞发育的调控：分子调控及其对免疫稳态和治疗的影响。
Blood. 2012 Apr 12;119(15):3383-93. doi: 10.1182/blood-2011-11-370130. Epub 2012 Feb 8.
9
Cytokine adjuvants for vaccine therapy of neoplastic and infectious disease.细胞因子佐剂在肿瘤和传染病疫苗治疗中的应用。
Cytokine Growth Factor Rev. 2011 Aug;22(4):177-87. doi: 10.1016/j.cytogfr.2011.07.001. Epub 2011 Aug 20.
10
GM-CSF induces bone marrow precursors of NOD mice to skew into tolerogenic dendritic cells that protect against diabetes.GM-CSF 诱导 NOD 小鼠的骨髓前体细胞向耐受原性树突状细胞分化，从而防止糖尿病的发生。
Cell Immunol. 2010;265(1):31-6. doi: 10.1016/j.cellimm.2010.06.010. Epub 2010 Jun 25.

Revisiting GM-CSF as an adjuvant for therapeutic vaccines.

作者信息

Zhao Weidong, Zhao Gan, Wang Bin

机构信息

Key Laboratory of Medical Molecular Virology of the Ministry of Health and Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

出版信息

Cell Mol Immunol. 2018 Feb;15(2):187-189. doi: 10.1038/cmi.2017.105. Epub 2017 Oct 23.

DOI:10.1038/cmi.2017.105
PMID:29057973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5811680/
Abstract
摘要