Department of Pathology & Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Cytokine Growth Factor Rev. 2011 Aug;22(4):177-87. doi: 10.1016/j.cytogfr.2011.07.001. Epub 2011 Aug 20.
Vaccination, the revolutionary prophylactic immunotherapy developed in the eighteenth century, has become the most successful and cost-effective of medical remedies available to modern society. Due to the remarkable accomplishments of the past century, the number of diseases and pathogens for which a traditional vaccine approach might reasonably be employed has dwindled to unprecedented levels. While this happy scenario bodes well for the future of public health, modern immunologists and vaccinologists face significant challenges if we are to address the scourge of recalcitrant pathogens like HIV and HCV and well as the significant obstacles to immunotherapy imposed by neoplastic self. Here, the authors review the clinical and preclinical literature to highlight the manner by which the host immune system can be successfully manipulated by cytokine adjuvants, thereby significantly enhancing the efficacy of a wide variety of vaccination platforms.
疫苗接种是 18 世纪发展起来的革命性预防性免疫疗法，已成为现代社会最成功和最具成本效益的医疗手段。由于上个世纪的显著成就，传统疫苗方法可合理应用的疾病和病原体数量已减少到前所未有的水平。虽然这种理想的情况预示着公共卫生的未来前景良好，但如果我们要解决 HIV 和 HCV 等顽固病原体的祸害，以及肿瘤自身对免疫疗法造成的重大障碍，现代免疫学家和疫苗学家仍面临重大挑战。在这里，作者回顾了临床和临床前文献，强调了细胞因子佐剂可以成功地操纵宿主免疫系统，从而显著提高各种疫苗平台的疗效。
