Peet M
Northern General Hospital, Sheffield, UK.
Postgrad Med J. 1988;64 Suppl 2:45-9.
Evidence supporting the efficacy of beta blockers in anxiety is reviewed. Propranolol and oxprenolol are the most clearly established in efficacy. A placebo-controlled trial is described, in which propranolol and atenolol were both effective in the symptomatic treatment of generalized anxiety in patients who had been referred by their family doctors for specialist treatment. If initial psychological treatment for chronic anxiety is ineffective, and a drug is considered necessary, then a beta blocker or an antidepressant should be considered as first choice in preference to a benzodiazepine.
本文综述了支持β受体阻滞剂治疗焦虑症有效性的证据。普萘洛尔和氧烯洛尔的疗效最为明确。文中描述了一项安慰剂对照试验，在该试验中，普萘洛尔和阿替洛尔对因全科医生转诊接受专科治疗的广泛性焦虑症患者的症状治疗均有效。如果慢性焦虑症的初始心理治疗无效，且认为有必要使用药物治疗，那么应优先考虑β受体阻滞剂或抗抑郁药作为首选，而非苯二氮䓬类药物。
