Institut Català Oncologia Badalona, Ct. Canyet, s/n, 08916, Barcelona, Spain.
Complejo Hospitalario Virgen del Rocío, Seville, Spain.
Clin Transl Oncol. 2018 Jan;20(1):16-21. doi: 10.1007/s12094-017-1762-7. Epub 2017 Oct 20.
The SEOM/GEINO clinical guidelines provide recommendations for radiological, and molecular diagnosis, treatment and follow-up of adult patients with anaplastic gliomas (AG). We followed the 2016 WHO classification which specifies the major diagnostic/prognostic and predictive value of IDH1/IDH2 missense mutations and 1p/19q codeletions in AG. The diagnosis of anaplastic oligoastrocytoma is discouraged. Surgery, radiotherapy and chemotherapy with PCV or TMZ are the first-line standard of care for AG with slight modifications according to molecular variables. A multidisciplinary team is highly recommended in the management of these tumors.
SEOM/GEINO 临床指南为成人间变性神经胶质瘤 (AG) 的放射学和分子诊断、治疗和随访提供了建议。我们遵循了 2016 年世界卫生组织的分类，该分类明确了 IDH1/IDH2 错义突变和 1p/19q 缺失在 AG 中的主要诊断/预后和预测价值。不鼓励对间变性少突星形细胞瘤进行诊断。手术、放疗和化疗联合 PCV 或 TMZ 是 AG 的一线标准治疗方法，根据分子变量略有修改。强烈建议在这些肿瘤的治疗中采用多学科团队。
