患有限制型神经性厌食症的年轻女孩的过度体育活动：其对心脏结构和功能的作用。
Excessive physical activity in young girls with restrictive-type anorexia nervosa: its role on cardiac structure and performance.
作者信息
Billeci Lucia, Brunori Elena, Scardigli Silvia, Curzio Olivia, Calderoni Sara, Maestro Sandra, Morales Maria Aurora
机构信息
Institute of Clinical Physiology, National Research Council of Italy (CNR), via Moruzzi 1, 56124, Pisa, Italy.
IRCCS Stella Maris Foundation, Viale del Tirreno 331, 56018, Calambrone, PI, Italy.
出版信息
Eat Weight Disord. 2018 Oct;23(5):653-663. doi: 10.1007/s40519-017-0447-0. Epub 2017 Oct 20.
PURPOSE
The aim of this study was to investigate the influence of hyperactivity on left ventricular mass (LVM) in Anorexia Nervosa restricting-type (AN-R) and the correlation between LVM and auxologic parameters/circulating hormones.
METHODS
Echocardiography was performed in 44 AN-R girls, subgrouped in 24 hyperactive (ANH+) and 20 non-hyperactive (ANH-), and in 20 controls (HC). LVM indexed to Body Surface Area (LVMi) and LVM indexed to height (LVMh) were calculated.
RESULTS
LVMi and LVMh were significantly lower in the AN-R subjects compared to HC. Moreover, both LVMi and LVMh were higher in the ANH+ than in the ANH-. In the HC, LVMi was higher when compared to the ANH- subjects than to the ANH+. Stepwise analysis revealed that in the ANH+ group, fT4 was the only independent predictor of LVMh, while in the ANH- group, height was the only independent predictors of LVMi.
CONCLUSIONS
Despite its negative influence on disease severity and outcome, hyperactivity from the standpoint of cardiac function makes the LVM of AN-R young girls more similar to HC.
LEVEL OF EVIDENCE
Level III, case-control study.
目的
本研究旨在探讨多动对神经性厌食限制型（AN-R）患者左心室质量（LVM）的影响，以及LVM与体格参数/循环激素之间的相关性。
方法
对44名AN-R女孩进行了超声心动图检查，将其分为24名多动组（ANH+）和20名非多动组（ANH-），并与20名对照组（HC）进行比较。计算了体表面积指数左心室质量（LVMi）和身高指数左心室质量（LVMh）。
结果
与HC相比，AN-R受试者的LVMi和LVMh显著降低。此外，ANH+组的LVMi和LVMh均高于ANH-组。在HC组中，与ANH-受试者相比，LVMi高于ANH+受试者。逐步分析显示，在ANH+组中，游离甲状腺素（fT4）是LVMh的唯一独立预测因子，而在ANH-组中，身高是LVMi的唯一独立预测因子。
结论
尽管多动对疾病严重程度和预后有负面影响，但从心脏功能的角度来看，多动使AN-R年轻女孩的LVM更接近HC组。
证据水平
III级，病例对照研究。
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