College of Materials Science and Engineering, Institute for, Graphene Applied Technology Innovation, Qingdao University, 308 Ningxia Road, Qingdao, China.
Chemistry. 2018 Mar 20;24(17):4215-4227. doi: 10.1002/chem.201704197. Epub 2017 Dec 22.
Novel nanomaterials and advanced nanotechnologies continue to promote the fast development of new approaches for efficient tumor therapy. As an alternative choice to various traditional therapies, non-invasive photothermal therapy (PTT) has attracted significant attention mainly due to its low cost, highly localizing, specific tumor treatment and minimal side effects on healthy tissues. PTT induced by photo-absorbing agents which can absorb and convert the external NIR laser into heat to ablate tumors. Plenty of studies have shown the significant potential of PTT to treat tumors in future practical applications. However, PTT alone usually could not eradicate tumors considering the intensity of laser gradual attenuates in biological tissues and the heat generated tends to distribute inhomogeneous within tumors tissues. Combination of chemotherapy with photothermal therapy into one system for tumor therapy is an effective strategy to further improve the therapy efficiency. In this Minireview, we focus on the recent advances in constructing PTT therapeutic and multi-model combination therapeutic via integrating nanomaterials and functional polymers.
新型纳米材料和先进纳米技术持续推动高效肿瘤治疗新方法的快速发展。光热疗法（PTT）作为各种传统疗法的替代选择，由于其成本低、定位准确、对肿瘤具有特异性且对健康组织的副作用极小，引起了人们的极大关注。光热疗法是由光吸收剂诱导的，光吸收剂可以吸收并将外部近红外激光转化为热量来消融肿瘤。大量研究表明，光热疗法在未来的实际应用中具有显著的治疗肿瘤的潜力。然而，考虑到激光在生物组织中的强度逐渐衰减以及产生的热量在肿瘤组织中分布不均匀，单独的 PTT 通常无法根除肿瘤。将化疗与光热疗法结合为一体的肿瘤治疗是进一步提高治疗效率的有效策略。在这篇综述中，我们专注于通过整合纳米材料和功能聚合物构建 PTT 治疗和多模式联合治疗的最新进展。
