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基于金属聚合物的药物递送系统的最新进展。

Recent advances in metallopolymer-based drug delivery systems.

作者信息

Dzhardimalieva Gulzhian I, Rabinskiy Lev N, Kydralieva Kamila A, Uflyand Igor E

机构信息

Laboratory of Metallopolymers, The Institute of Problems of Chemical Physics RAS Academician Semenov Avenue 1 Chernogolovka Moscow Region 142432 Russian Federation

Moscow Aviation Institute (National Research University) Volokolamskoe Shosse, 4 Moscow 125993 Russia

出版信息

RSC Adv. 2019 Nov 13;9(63):37009-37051. doi: 10.1039/c9ra06678k. eCollection 2019 Nov 11.

DOI:10.1039/c9ra06678k
PMID:35539076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9075603/
Abstract

Metallopolymers (MPs) or metal-containing polymers have shown great potential as new drug delivery systems (DDSs) due to their unique properties, including universal architectures, composition, properties and surface chemistry. Over the past few decades, the exponential growth of many new classes of MPs that deal with these issues has been demonstrated. This review presents and assesses the recent advances and challenges associated with using MPs as DDSs. Among the most widely used MPs for these purposes, metal complexes based on synthetic and natural polymers, coordination polymers, metal-organic frameworks, and metallodendrimers are distinguished. Particular attention is paid to the stimulus- and multistimuli-responsive metallopolymer-based DDSs. Of considerable interest is the use of MPs for combination therapy and multimodal systems. Finally, the problems and future prospects of using metallopolymer-based DDSs are outlined. The bibliography includes articles published over the past five years.

摘要

金属聚合物（MPs）或含金属聚合物因其独特的性质，包括通用的结构、组成、性质和表面化学，已显示出作为新型药物递送系统（DDSs）的巨大潜力。在过去几十年中，已证明处理这些问题的许多新型MPs呈指数增长。本综述介绍并评估了与将MPs用作DDSs相关的最新进展和挑战。在为此目的最广泛使用的MPs中，基于合成和天然聚合物的金属配合物、配位聚合物、金属有机框架和金属树枝状大分子脱颖而出。特别关注基于刺激和多刺激响应的金属聚合物的DDSs。使用MPs进行联合治疗和多模式系统具有相当大的研究价值。最后，概述了使用基于金属聚合物的DDSs的问题和未来前景。参考文献包括过去五年发表的文章。

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ACS Biomater Sci Eng. 2018 Dec 10;4(12):4183-4192. doi: 10.1021/acsbiomaterials.8b00840. Epub 2018 Nov 21.
8
A core-shell metal-organic-framework (MOF)-based smart nanocomposite for efficient NIR/HO-responsive photodynamic therapy against hypoxic tumor cells.一种基于核壳金属有机框架（MOF）的智能纳米复合材料，用于对缺氧肿瘤细胞进行高效的近红外/过氧化氢响应性光动力治疗。
J Mater Chem B. 2017 Apr 7;5(13):2390-2394. doi: 10.1039/c7tb00314e. Epub 2017 Mar 20.
9
Creation and bioapplications of porous organic polymer materials.多孔有机聚合物材料的制备及其生物应用
J Mater Chem B. 2017 Dec 21;5(47):9278-9290. doi: 10.1039/c7tb02647a. Epub 2017 Nov 20.
10
Metal organic frameworks based on bioactive components.基于生物活性成分的金属有机框架。
J Mater Chem B. 2017 Apr 14;5(14):2560-2573. doi: 10.1039/c6tb03217f. Epub 2017 Feb 27.