Fragala Maren S, Bi Caixia, Chaump Michael, Kaufman Harvey W, Kroll Martin H
Quest Diagnostics, 3 Giralda Farms, Madison, NJ, United States of America.
PLoS One. 2017 Oct 23;12(10):e0180840. doi: 10.1371/journal.pone.0180840. eCollection 2017.
Physical exercise may affect levels of blood-based biomarkers. However, exercise status is seldom considered in the interpretation of laboratory results. This study reports the associations between habitual exercise participation and clinical laboratory test results.
The effects of days per week of aerobic and strength exercise participation on laboratory test results for 26 biomarkers in young adults aged 18 to 34 years (n = 80,111) were evaluated using percentile distribution analyses and multivariate regression.
In both men and women, more days per week of either aerobic or strength exercise were significantly associated with lower levels of glucose, hemoglobin A1c, LDL cholesterol, total cholesterol, triglycerides, estimated glomerular filtration rate, globulin, and C-reactive protein, and significantly higher levels of HDL cholesterol, creatinine, iron, and percent saturation (all p < .05). Type of exercise or gender influenced the observed relationships with exercise frequency for total cholesterol, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, uric acid, bilirubin, and iron binding capacity.
Physical exercise shifted the distribution of results into the direction suggestive of better health. Reported relationships may help clinicians and patients to better understand and interpret laboratory results in athletic populations and possibly re-evaluate interpretation of reference intervals for physically active populations.
体育锻炼可能会影响血液中生物标志物的水平。然而，在解释实验室检查结果时很少考虑运动状态。本研究报告了习惯性运动参与与临床实验室检查结果之间的关联。
采用百分位数分布分析和多变量回归，评估了18至34岁年轻成年人（n = 80,111）每周进行有氧运动和力量训练的天数对26种生物标志物实验室检查结果的影响。
在男性和女性中，每周进行更多天数的有氧运动或力量训练均与较低的血糖、糖化血红蛋白、低密度脂蛋白胆固醇、总胆固醇、甘油三酯、估算肾小球滤过率、球蛋白和C反应蛋白水平显著相关，且与较高的高密度脂蛋白胆固醇、肌酐、铁和饱和度百分比水平显著相关（所有p < 0.05）。运动类型或性别影响了总胆固醇、天冬氨酸转氨酶、γ-谷氨酰转移酶、碱性磷酸酶、尿酸、胆红素和铁结合能力与运动频率之间的观察关系。
体育锻炼使检查结果的分布朝着提示更健康的方向转变。报告的这些关系可能有助于临床医生和患者更好地理解和解释运动员群体的实验室检查结果，并可能重新评估体力活动人群参考区间的解释。
