Sarıtekin İlker, Açıkgöz Şerefden, Bayraktaroğlu Taner, Kuzu Fatih, Can Murat, Güven Berrak, Mungan Görkem, Büyükuysal Çağatay, Sarıkaya Selda
Department of Biochemistry, Faculty of Medicine, Bülent Ecevit University, 67630 Zonguldak, Turkey.
Department of Endocrine and Metabolism, Faculty of Medicine, Bülent Ecevit University, 67630 Zonguldak, Turkey.
Acta Biochim Pol. 2017;64(4):597-602. doi: 10.18388/abp.2016_1303. Epub 2017 Oct 25.
Sclerostin, which is a glycoprotein produced by osteocytes, reduces the formation of bones by inhibiting the Wnt signal pathway. Thyroid hormones are related with Wnt signal pathway and it has been reported that increased thyroid hormones in hyperthyroidism fasten epiphysis maturation in childhood, and increase the risk of bone fractures by stimulating the bone loss in adults. The aim of this study was to examine the sclerostin serum levels, the relation between sclerostin and thyroid hormones as well as the biochemical markers of the bone metabolism in patients with hyperthyroidism (including multinodular goiter and Graves' disease), whose treatments have not started yet. No difference was found in the serum sclerostin levels between the hyperthyroidism group (n=24) and the control group (n=24) (p=0.452). The serum osteocalcin levels and 24-hour urinary phosphorus excretion were found to be higher in the hyperthyroid group than in the control group (p<0.001, p=0.009). A positive correlation was determined between the sclerostin and bone alkaline phosphatase levels (p<0.001); a negative correlation between the osteocalcin and thyroid stimulating hormone (TSH) (p<0.05); a positive correlation between the osteocalcin and thyroid hormones (FT,FT) (p<0.001); and a positive correlation between the deoxypyridinoline and hydroxyproline (p<0.001). No correlation was determined between sclerostin and TSH,FT,FT (p>0.05). Therefore, we consider that a long-term study that covers the pre-post treatment stages of hyperthyroidism, including both the destruction and construction of the skeleton would be more enlightening. Moreover, the assessment of the synthesis of sclerostin in the bone tissue and in the serum level might show differences.
硬化素是一种由骨细胞产生的糖蛋白，它通过抑制Wnt信号通路来减少骨形成。甲状腺激素与Wnt信号通路相关，据报道，甲状腺功能亢进症患者甲状腺激素增加会加速儿童骨骺成熟，并通过刺激成人骨质流失增加骨折风险。本研究的目的是检测未经治疗的甲状腺功能亢进症患者（包括多结节性甲状腺肿和格雷夫斯病）的血清硬化素水平、硬化素与甲状腺激素之间的关系以及骨代谢的生化标志物。甲状腺功能亢进症组（n = 24）和对照组（n = 24）的血清硬化素水平无差异（p = 0.452）。甲状腺功能亢进组的血清骨钙素水平和24小时尿磷排泄量高于对照组（p < 0.001，p = 0.009）。硬化素与骨碱性磷酸酶水平之间呈正相关（p < 0.001）；骨钙素与促甲状腺激素（TSH）之间呈负相关（p < 0.05）；骨钙素与甲状腺激素（FT、FT）之间呈正相关（p < 0.001）；脱氧吡啶啉与羟脯氨酸之间呈正相关（p < 0.001）。硬化素与TSH、FT、FT之间未发现相关性（p > 0.05）。因此，我们认为一项涵盖甲状腺功能亢进症治疗前后阶段的长期研究，包括骨骼的破坏和构建，会更有启发性。此外，对骨组织中硬化素合成和血清水平的评估可能会显示出差异。
