Couto Adriana
Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul;2017:181-184. doi: 10.1109/EMBC.2017.8036792.
Among all infections, urinary tract infections (UTI) are one of the most common. Nowadays the procedures to analyze urine and consequently detect UTI are often painful and time-consuming. Recent studies about microfluidic paper-based devices have developed the interest of researchers due their outstanding characteristics. In this paper is presented a novel design for a microfluidic paper-based device for screening and analysis of multiple biomarkers from urine samples on diapers. The device consists on a set of eight layers. It was designed based on the previous attempts to improve and overcome some problems detected as the continuous entrance of fluids, the possibility of contamination and the invalidity of results due to communication between different reagent pads. One approach was create a "self-locking" mechanism that closes the sample inlet in approximately four minutes solving the first two problems. Furthermore, is important that comfort is guaranteed, hence a device with a total thickness of 5,3 mm is presented. This device can keep the results for eight hours and can be used as a low-cost and more effective alternative than conventional methods being a strategy with potential for the diagnostic and analysis of biological samples in the future improving healthcare.
在所有感染中，尿路感染（UTI）是最常见的感染之一。如今，分析尿液并进而检测尿路感染的程序通常既痛苦又耗时。最近关于微流控纸基装置的研究因其卓越的特性引起了研究人员的兴趣。本文介绍了一种新颖的微流控纸基装置设计，用于从尿布上的尿液样本中筛选和分析多种生物标志物。该装置由八层组成。它是基于先前的尝试设计的，旨在改进和克服一些检测到的问题，如液体的持续流入、污染的可能性以及由于不同试剂垫之间的连通导致结果无效。一种方法是创建一种“自锁”机制，该机制在大约四分钟内关闭样品入口，解决了前两个问题。此外，保证舒适度很重要，因此展示了一种总厚度为5.3毫米的装置。该装置可以保持结果八小时，并且可以作为比传统方法成本更低、更有效的替代方案，是一种未来在生物样本诊断和分析方面具有潜力的策略，有望改善医疗保健。
