Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul;2017:1513-1516. doi: 10.1109/EMBC.2017.8037123.
Effects of high frequency repetitive transcranial magnetic stimulation (rTMS) with a subthreshold intensity on hemodynamic response in brain cortices (both motor and prefrontal cortices) was investigated using the functional near infrared spectroscopy (fNIRS) technique. FNIRS signals of the motor and prefrontal cortices were acquired in healthy volunteers (n=7) at rest and during rTMS intervention. A significant reduction in oxygenated hemoglobin (HbO) concentration during the entire stimulation process was observed from both motor and prefrontal cortices. Results showed that the fNIRS technique can provide a reliable measure of regional cortical brain activation that could be valuable in studying cortical excitability connectivity in combination with rTMS.
采用功能近红外光谱（fNIRS）技术，研究了阈下强度高频重复经颅磁刺激（rTMS）对大脑皮层（运动和前额叶皮层）血流动力学反应的影响。在静息状态和rTMS干预期间，采集了7名健康志愿者运动和前额叶皮层的fNIRS信号。在整个刺激过程中，运动和前额叶皮层的氧合血红蛋白（HbO）浓度均显著降低。结果表明，fNIRS技术能够可靠地测量局部皮层脑激活，这对于结合rTMS研究皮层兴奋性连接可能具有重要价值。
