Cancer Biomark. 2017 Dec 12;21(1):29-39. doi: 10.3233/CBM-170177.
Detecting volatile organic compounds (VOCs) could provide a rapid, noninvasive, and inexpensive screening tool for detecting cancer.
In this systematic review, we identified specific exhaled breath VOCs correlated with lung, colorectal, and breast cancer.
We identified relevant studies published in 2015 and 2016 by searching Pubmed and Web of Science. The protocol for this systematic review was registered in PROSPERO and the PRISMA guidelines were used in reporting. VOCs and performance data were extracted.
Three hundred and thirty three records were identified and 43 papers were included in the review, of which 20 were review articles themselves. We identified 17 studies that listed the VOCs with at least a subset of statistics on detection cutoff levels, sensitivity, specificity, area under the receiver operating characteristic curve (AUC), and gradient.
Breath analysis for cancer screening and early detection shows promise, because samples can be collected easily, safely, and frequently. While gas chromatography-mass spectrometry is considered the gold standard for identifying specific VOCs, breath analysis has moved into analyzing patterns of VOCs using a variety of different multiple sensor techniques, such as eNoses and nanomaterials. Further development of VOCs for early cancer detection requires clinical trials with standardized breath sampling methods.
检测挥发性有机化合物（VOCs）可为癌症的快速、非侵入性和低成本筛查提供工具。
在本系统综述中，我们确定了与肺癌、结直肠癌和乳腺癌相关的特定呼气 VOCs。
我们通过搜索 Pubmed 和 Web of Science 确定了 2015 年和 2016 年发表的相关研究。本系统综述的方案已在 PROSPERO 中注册，并按照 PRISMA 指南进行报告。提取了 VOC 和性能数据。
共确定了 333 条记录，有 43 篇论文被纳入综述，其中 20 篇本身就是综述文章。我们确定了 17 项研究，列出了至少具有部分检测截断水平、敏感性、特异性、接收者操作特征曲线下面积（AUC）和梯度统计数据的 VOCs。
呼气分析在癌症筛查和早期检测方面显示出前景，因为可以轻松、安全和频繁地采集样本。虽然气相色谱-质谱法被认为是识别特定 VOCs 的金标准，但呼气分析已经发展到使用各种不同的多传感器技术（如电子鼻和纳米材料）来分析 VOC 模式。为了实现早期癌症检测中 VOCs 的进一步发展，需要采用标准化的呼气采样方法进行临床试验。
