Department of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Front Public Health. 2023 Jul 5;11:1210136. doi: 10.3389/fpubh.2023.1210136. eCollection 2023.
Volatile organic compounds (VOCs) are a large group of chemicals widely used in People's Daily life. There is increasing evidence of the cumulative toxicity of VOCs. However, the association between VOCs and the risk of COPD has not been reported.
We comprehensively evaluated the association between VOCs and COPD.
Our study included a total of 1,477 subjects from the National Health and Nutrition Examination Survey, including VOCs, COPD, and other variables in the average US population. Multiple regression models and smooth-curve fitting (penalty splines) were constructed to examine potential associations, and stratified analyses were used to identify high-risk groups.
We found a positive association between blood benzene and blood o-xylene concentrations and COPD risk and identified a concentration relationship between the two. That is, when the blood benzene and O-xylene concentrations reached 0.28 ng/mL and 0.08 ng/mL, respectively, the risk of COPD was the highest. In addition, we found that gender, age, and MET influence the relationship, especially in women, young people, and people with low MET.
This study revealed that blood benzene and blood o-xylene were independently and positively correlated with COPD risk, suggesting that long-term exposure to benzene and O-xylene may cause pulmonary diseases, and providing a new standard of related blood VOCs concentration for the prevention of COPD.
挥发性有机化合物（VOCs）是一组广泛应用于日常生活的化学品。越来越多的证据表明 VOCs 具有累积毒性。然而，VOCs 与 COPD 风险之间的关联尚未报道。
我们全面评估了 VOCs 与 COPD 之间的关联。
我们的研究共纳入了来自全国健康和营养调查的 1477 名受试者，包括美国普通人群中的 VOCs、COPD 及其他变量。构建了多元回归模型和光滑曲线拟合（惩罚样条）来检验潜在的关联，并进行了分层分析以确定高危人群。
我们发现血液中苯和邻二甲苯浓度与 COPD 风险呈正相关，并确定了两者之间的浓度关系。即当血液中苯和邻二甲苯浓度分别达到 0.28ng/ml 和 0.08ng/ml 时，COPD 风险最高。此外，我们发现性别、年龄和 MET 会影响这种关系，尤其是在女性、年轻人和 MET 较低的人群中。
本研究表明血液中苯和邻二甲苯与 COPD 风险呈独立正相关，提示长期暴露于苯和邻二甲苯可能会导致肺部疾病，为预防 COPD 提供了新的相关血液 VOCs 浓度标准。
