AbdelRazek Mahmoud, Stone John H
Department of Neurology, Mayo clinic, 200 First Street. SouthWest Rochester, MN 55905, USA.
Rheumatology Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Rheum Dis Clin North Am. 2017 Nov;43(4):621-631. doi: 10.1016/j.rdc.2017.06.010.
Immunoglobulin G4-related disease (IgG4-RD) can involve nearly any organ system, including the central and peripheral nervous systems. IgG4 antibodies are not known to play a primary etiologic role in disease. IgG4-RD must be distinguished from a growing number of immune-mediated conditions in which IgG4 autoantibodies contribute directly to pathophysiology. The most common neurologic features of IgG4-RD result from disease in the orbits, pachymeninges, and substance of the pituitary gland and stalk, as well as a perineuropathy that can involve peripheral or cranial nerves. Disease affecting the brain parenchyma is rare but reported.
免疫球蛋白G4相关疾病（IgG4-RD）几乎可累及任何器官系统，包括中枢和周围神经系统。目前尚不清楚IgG4抗体在该疾病中起主要病因作用。IgG4-RD必须与越来越多的免疫介导疾病相鉴别，在这些疾病中IgG4自身抗体直接参与病理生理过程。IgG4-RD最常见的神经学特征源于眼眶、硬脑膜、垂体及其柄部的病变，以及可累及周围或颅神经的周围神经病。影响脑实质的疾病虽罕见但有报道。
