Imboden John B
Department of Medicine, University of California, Box 0868, San Francisco, CA 94143, USA.
Rheum Dis Clin North Am. 2017 Nov;43(4):633-639. doi: 10.1016/j.rdc.2017.06.011. Epub 2017 Aug 19.
Peripheral nerve involvement is common in polyarteritis nodosa and the antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides. The underlying mechanism is arteritis of the vasa nervorum, leading to ischemic neuropathy. The classic presentation is stepwise involvement of peripheral nerves with ongoing antecedent constitutional symptoms. This article reviews the pathologic findings, clinical syndromes, diagnosis, and treatment of ANCA-associated vasculitides.
周围神经受累在结节性多动脉炎和抗中性粒细胞胞浆抗体(ANCA)相关血管炎中很常见。其潜在机制是营养神经血管的动脉炎,导致缺血性神经病变。典型表现是周围神经呈进行性累及,并伴有前驱全身症状。本文综述了ANCA相关血管炎的病理表现、临床综合征、诊断及治疗。