Morin Caroline, Fortin Samuel
SCF Pharma, Ste-Luce, QC, Canada.
SCF Pharma, Ste-Luce, QC, Canada
Anticancer Res. 2017 Nov;37(11):6015-6023. doi: 10.21873/anticanres.12048.
BACKGROUND/AIM: Omega 3 polyunsaturated fatty acids (PUFAs) have been shown to inhibit the induction and progression of many tumor types. The aim of this study was to determine the anticancer effect of docosahexaenoic acid monoglyceride (MAG-DHA) alone and in combination with the chemotherapeutic agent carboplatin (CBT) on lung cancer models.
Adenocarcinoma cell lines A549 and H1299 were used to evaluate the effect of combined MAG-DHA and CBT treatments both in vitro and in vivo in xenograft models.
MAG-DHA+CBT treatment decreased cell proliferation and invasion abilities of A549 and H1299 cells. Furthermore, MAG-DHA+CBT treatment resulted in a decreased activation of epithelial growth factor receptor (EGFR) and its downstream extracellular signal-regulated kinase (ERK) in cell lysates. In A549 and H1299 xenograft mouse models, MAG-DHA+CBT treatment reduced tumor growth.
Combined MAG-DHA and CBT treatment inhibited tumor growth by suppressing EGFR and ERK signaling pathways in lung carcinoma cells.
背景/目的：ω-3多不饱和脂肪酸（PUFAs）已被证明可抑制多种肿瘤类型的诱导和进展。本研究的目的是确定二十二碳六烯酸单甘油酯（MAG-DHA）单独以及与化疗药物卡铂（CBT）联合使用对肺癌模型的抗癌作用。
使用腺癌细胞系A549和H1299在异种移植模型中体外和体内评估MAG-DHA与CBT联合治疗的效果。
MAG-DHA + CBT治疗降低了A549和H1299细胞的增殖和侵袭能力。此外，MAG-DHA + CBT治疗导致细胞裂解物中表皮生长因子受体（EGFR）及其下游细胞外信号调节激酶（ERK）的激活减少。在A549和H1299异种移植小鼠模型中，MAG-DHA + CBT治疗减少了肿瘤生长。
MAG-DHA与CBT联合治疗通过抑制肺癌细胞中的EGFR和ERK信号通路来抑制肿瘤生长。
