Luo Jiang, Peng Shu, Jiang Ziyu, Wang Qingwei, Zhang Mini, Zeng Yuxin, Yuan Yu, Xia Min, Hong Zixi, Yan Yufei, Tan Yushuang, Tang Jiawen, Xie Conghua, Gong Yan
Department of Pulmonary Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Tumor Precision Diagnosis and Treatment Technology and Translational Medicine, Hubei Engineering Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
iScience. 2024 Dec 14;28(1):111601. doi: 10.1016/j.isci.2024.111601. eCollection 2025 Jan 17.
Over the past decades, researchers have continuously investigated the potential functions of long-chain polyunsaturated fatty acids (LCPUFAs) in cancers, including lung cancer. The ω-3 LCPUFAs, primarily consisting of eicosapentaenoic acid and docosahexaenoic acid, were found to modify inflammatory tumor microenvironment, induce cancer cell apoptosis and autophagy, and suppress tumor development when administered alone or with other therapeutical strategies. Although the precise anti-tumor mechanism has not been elucidated yet, ω-3 LCPUFAs are often used in the nutritional treatment of patients with cancer due to their ability to significantly improve patient's nutritional status, increase the sensitivity of tumor cells to treatments, and alleviate cancer-related complications. Here we present the key roles of ω-3 LCPUFAs as dietary supplementations in lung cancer, comprehensively review the recent progress on the underlying mechanisms of cancer cell regulation by ω-3 LCPUFAs, and introduce the application of ω-3 LCPUFAs in the clinical management of lung cancer and its malignant complications.
在过去几十年中，研究人员一直在持续研究长链多不饱和脂肪酸（LCPUFAs）在包括肺癌在内的癌症中的潜在作用。ω-3 LCPUFAs主要由二十碳五烯酸和二十二碳六烯酸组成，研究发现，单独使用或与其他治疗策略联合使用时，它们可改变炎性肿瘤微环境，诱导癌细胞凋亡和自噬，并抑制肿瘤发展。尽管其确切的抗肿瘤机制尚未阐明，但ω-3 LCPUFAs因其能够显著改善患者营养状况、提高肿瘤细胞对治疗的敏感性以及减轻癌症相关并发症，常被用于癌症患者的营养治疗。在此，我们阐述了ω-3 LCPUFAs作为膳食补充剂在肺癌中的关键作用，全面综述了ω-3 LCPUFAs调控癌细胞潜在机制的最新进展，并介绍了ω-3 LCPUFAs在肺癌临床管理及其恶性并发症中的应用。
