研磨参数对活化β-环糊精亲核取代反应的影响。
Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins.
作者信息
Jicsinszky László, Tuza Kata, Cravotto Giancarlo, Porcheddu Andrea, Delogu Francesco, Colacino Evelina
机构信息
Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, via P. Giuria 9, 10125 Turin, Italy.
Cyclolab Cyclodextrin R&D Laboratory, Ltd., Illatos út 7, 1192 Budapest, Hungary.
出版信息
Beilstein J Org Chem. 2017 Sep 7;13:1893-1899. doi: 10.3762/bjoc.13.184. eCollection 2017.
The present work focuses on the mechanochemical preparation of industrially important β-cyclodextrin (CD) derivatives. Activated CDs have been reacted with nitrogen and sulfur nucleophiles using a planetary mill equipped with stainless steel, zirconia and glass milling tools of different sizes. It is shown that the milling frequency and the number as well as the size of the milling balls have an effect on the nucleophilic reaction.
目前的工作重点是工业上重要的β-环糊精（CD）衍生物的机械化学制备。使用配备有不同尺寸不锈钢、氧化锆和玻璃研磨工具的行星式球磨机，使活化的环糊精与氮和硫亲核试剂发生反应。结果表明，研磨频率、研磨球的数量和尺寸对亲核反应有影响。
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