Adeoye Oluwatomide, Cabral-Marques Helena
Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia da Universidade de Lisboa, Avenida Prof. Gama Pinto, 1649-003 Lisboa, Portugal; Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia da Universidade de Lisboa, Avenida Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
Int J Pharm. 2017 Oct 15;531(2):521-531. doi: 10.1016/j.ijpharm.2017.04.050. Epub 2017 Apr 26.
Oral delivery of many therapeutic agents remains challenging due to gastric insolubility/poor dissolution, inefficient intestinal permeability and pre-systemic inactivation. These problems limit the advantages of convenience and increased compliance they provide in the therapy of many chronic diseases. Cyclodextrin nanosystems have emerged as promising platforms for drug-specific construction of the oral delivery nanosystems able to optimize the desired physicochemical properties and pharmacokinetic parameters; without a compromise on safety. This review focuses on some recent and encouraging advances in the application of cyclodextrin nanosystems for oral drug delivery. A general overview of cyclodextrins and pharmaceutical nanotechnology in oral delivery systems is provided. Some of the strategies being exploited for the synthesis of these nanosystems, and their potential for the intelligent navigation of the gastrointestinal tract for optimal bioavailability and biodistribution are then illustrated. Perspectives for translating these nanosystems from laboratory efficient formulations to clinically useful medicines are also discussed.
由于药物在胃中的不溶性/溶解性差、肠道渗透性低以及首过效应导致的前体药物失活，许多治疗药物的口服给药仍然具有挑战性。这些问题限制了口服给药在许多慢性疾病治疗中所具有的便利性和提高患者依从性的优势。环糊精纳米系统已成为构建口服给药纳米系统的有前景的平台，该系统能够针对特定药物优化所需的物理化学性质和药代动力学参数，同时不影响安全性。本综述重点介绍了环糊精纳米系统在口服药物递送应用方面的一些最新且令人鼓舞的进展。文中提供了环糊精和口服给药系统中的药物纳米技术的概述。接着阐述了用于合成这些纳米系统的一些策略，以及它们在胃肠道中实现智能导航以实现最佳生物利用度和生物分布的潜力。还讨论了将这些纳米系统从实验室高效制剂转化为临床可用药物的前景。
