Vicini J L, Clark J H, Hurley W L, Bahr J M
Department of Animal Sciences, University of Illinois, Urbana 61801.
Domest Anim Endocrinol. 1988 Jan;5(1):35-45. doi: 10.1016/0739-7240(88)90024-0.
Holstein calves were used to investigate the effects of immunization procedures against somatostatin (SRIF) on growth and concentrations of somatotropin in plasma. In Trial 1, eight heifers 37 weeks of age were inoculated with cyclic-SRIF conjugated to human alpha-globulin. Final body weight, average daily gain, and measurements of body size were not significantly different between control and SRIF-immunized calves. Apparent total tract nutrient digestibilities and efficiency of feed utilization also were not significantly different between treatments. Plasma concentrations of somatotropin were increased and plasma concentrations of urea nitrogen were decreased in calves immunized against SRIF compared to controls, but these mean differences were not significant. In Trial 2, eleven bull calves seven weeks of age were inoculated with cyclic-SRIF conjugated to keyhole limpet hemocyanin. Calves immunized against SRIF had larger average daily gains (P less than .06) than did control calves. Body size, efficiency of feed utilization, and concentrations of somatotropin in plasma were not significantly different for SRIF immunized calves and control calves. Urea nitrogen in plasma was lower (P less than .04) for calves immunized against somatostatin than for control calves. Data indicate that Holstein calves can produce auto-antibodies against SRIF; however, additional research will be required before such immunization techniques can be effectively used to improve weight gains in cattle.
选用荷斯坦犊牛来研究针对生长抑素（SRIF）的免疫程序对其生长及血浆中生长激素浓度的影响。在试验1中，给8头37周龄的小母牛接种与人α-球蛋白偶联的环状SRIF。对照犊牛和经SRIF免疫的犊牛在最终体重、平均日增重及体尺测量方面无显著差异。不同处理之间的表观全消化道养分消化率和饲料利用效率也无显著差异。与对照组相比，经SRIF免疫的犊牛血浆中生长激素浓度升高，血浆尿素氮浓度降低，但这些平均差异不显著。在试验2中，给11头7周龄的公犊牛接种与钥孔戚血蓝蛋白偶联的环状SRIF。经SRIF免疫的犊牛比对照犊牛平均日增重更大（P小于0.06）。经SRIF免疫的犊牛与对照犊牛在体尺、饲料利用效率及血浆中生长激素浓度方面无显著差异。经生长抑素免疫的犊牛血浆中的尿素氮比对照犊牛更低（P小于0.04）。数据表明荷斯坦犊牛能够产生针对SRIF的自身抗体；然而，在这种免疫技术能够有效用于提高牛的体重增加之前，还需要进一步研究。
