Chen Xiang, Wang Fei-Yu, Chu Guo-Jun, Zhu Yu-Feng, Tan Hong-Wen, Zhao Xian-Xian, Qin Yong-Wen, Ge Jun-Bo
Department of Cardiology, ZhongShan Hospital, Fudan University, Shanghai 200032, China.
Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Chronic Dis Transl Med. 2015 Jul 4;1(2):73-80. doi: 10.1016/j.cdtm.2015.06.005. eCollection 2015 Jun.
To evaluate the feasibility and satefy of transcatheter aortic valve implantation in animals by using a new balloon-expanding valved stent.
The balloon-expandable stent is made from cobalt-based alloy material and designed with a tubular, slotted structure. Fresh bovine pericardium was treated, sutured and fixed on the balloon-expandable stent. Ten healthy sheep (five males and five females), weighing an average of (25.16 ± 1.83) kg, were selected to undergo transcatheter implantation of the valve stents. The function of the valve stent was evaluated by angiography, echocardiography, and histology six months after the procedure.
Of the ten experimental sheep, two sheep died during the operation because the higher position of the artificial valve affected the opening of the coronary artery. We successfully implanted the aortic valve stent in other eight sheep; however, one sheep died of heart failure two weeks after the operation due to the lower position of the valve stent. The valve stents were implanted in the desired position in seven sheep. Ascending aortic angiographic and autoptic findings immediately after the operation confirmed the satisfactory location and function of the valved stent. Echocardiography, angiography, and histology at six postoperative months confirmed the satisfactory location and function of the valve stent.
We successfully implanted our new valve stent as a replacement of native aortic valve via the transcatheter route with satisfactory outcome.
通过使用新型球囊扩张带瓣支架评估经导管主动脉瓣植入术在动物中的可行性和安全性。
球囊扩张支架由钴基合金材料制成，设计为管状、带槽结构。对新鲜牛心包进行处理、缝合并固定在球囊扩张支架上。选择10只健康绵羊（5只雄性和5只雌性），平均体重为（25.16±1.83）kg，进行经导管瓣膜支架植入术。术后6个月通过血管造影、超声心动图和组织学评估瓣膜支架的功能。
10只实验绵羊中，2只绵羊在手术过程中死亡，原因是人工瓣膜位置较高影响冠状动脉开口。我们成功地在其他8只绵羊中植入了主动脉瓣膜支架；然而，1只绵羊在术后两周因瓣膜支架位置较低死于心力衰竭。7只绵羊的瓣膜支架被植入到理想位置。术后立即进行的升主动脉血管造影和尸检结果证实带瓣支架的位置和功能令人满意。术后6个月的超声心动图、血管造影和组织学检查证实瓣膜支架的位置和功能令人满意。
我们成功地通过经导管途径植入了新型瓣膜支架来替代天然主动脉瓣，结果令人满意。
