Ou-Yang Lin, Lu Guang-Ming
Department of Medical Imaging, PLA 175th Hospital, Southeast Hospital, Clinical School of Medical College, Xiamen University, Zhangzhou, Fujian, China.
Department of Medical Imaging, Nanjing General Hospital, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, Jiangsu, China.
Chronic Dis Transl Med. 2015 Jun 23;1(2):96-104. doi: 10.1016/j.cdtm.2015.02.007. eCollection 2015 Jun.
Using a dynamic computed tomographic perfusion (CTP) imaging method to explore the age-related distribution of the microcirculation perfusion function in the vertebral marrow, the bone material density (BMD), and the intervertebral discal degeneration (IDD). Further, to discuss a possible causation relationship between them.
One hundred and eighty-six people were randomly enrolled by stratified sampling and grouped by age: ≤15, 16-25, 26-35, 36-45, 46-55, 56-65, 66-75, and ≥76 years old. The average CTP and BMD of the third and fourth lumbar vertebrae marrow were measured and the IDD incidence of the third-fourth vertebrae was assessed. The temporal-spatial distribution patterns of the age-related changes of the CTP, BMD, and IDD were described, and the correlations between them were calculated.
The microcirculatory perfusion function of the vertebral marrow develops to maturity by 25 years and is maintained until age 35, then declines with aging. The BMD grew to a peak from 26 to 45 years old, then decreased yearly. The IDD showed a sudden increase after 45 years of age. The CTP [BF ( = 0.806, = 0.000), BV ( = 0.685, = 0.005) and PMB ( = 0.619, = 0.001)] showed strong positive correlations and CTP [TTP ( = -0.211, = 0.322) and MTT ( = -0.598, = 0.002)] showed negative correlations with BMD. The CTP [BF ( = -0.815, = 0.000), BV ( = -0.753, = 0.000) and PMB ( = -0.690, = 0.000)] had strong negative correlations, and CTP [TTP ( = 0.323, = 0.126) and MTT ( = 0.628, = 0.001)] had positive correlations with the incidence of IDD.
The decrease with aging of the microcirculatory perfusion in the lumbar vertebral marrow preceded, and is a potential causative factor for the loss of BMD and the onset of IDD.
采用动态计算机断层扫描灌注（CTP）成像方法，探究椎骨骨髓中微循环灌注功能、骨材料密度（BMD）及椎间盘退变（IDD）的年龄相关分布情况。此外，探讨它们之间可能的因果关系。
通过分层抽样随机纳入186人，并按年龄分组：≤15岁、16 - 25岁、26 - 35岁、36 - 45岁、46 - 55岁、56 - 65岁、66 - 75岁和≥76岁。测量第三和第四腰椎骨髓的平均CTP和BMD，并评估第三至第四椎体的IDD发生率。描述CTP、BMD和IDD年龄相关变化的时空分布模式，并计算它们之间的相关性。
椎骨骨髓的微循环灌注功能在25岁时发育成熟并维持至35岁，然后随年龄增长而下降。BMD在26至45岁时增长至峰值，然后逐年下降。IDD在45岁后突然增加。CTP[BF（ = 0.806， = 0.000），BV（ = 0.685， = 0.005）和PMB（ = 0.619， = 0.001）]与BMD呈强正相关，CTP[TTP（ = -0.211， = 0.322）和MTT（ = -0.598， = 0.002）]与BMD呈负相关。CTP[BF（ = -0.815， = .000），BV（ = -0.753， = ）和PMB（ = -0.690， = 0.000）]呈强负相关，CTP[TTP（ = 0.323， = 0.126）和MTT（ = 0.628， = 0.001）]与IDD发生率呈正相关。
腰椎骨髓微循环灌注随年龄增长而下降，且是BMD丢失和IDD发病的潜在致病因素。
