Zhang En-Yuan, Kou Lu, Li Min, Ng Chee Yuan, Zhao Jian-Ping, Li Guang-Ping, Liu Tong
Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Tianjin Chest Hospital, Tianjin 300051, China.
Chronic Dis Transl Med. 2016 Apr 6;2(1):27-33. doi: 10.1016/j.cdtm.2016.02.002. eCollection 2016 Mar.
Recent observational studies have suggested that the patients with hyperuricemia have a higher risk of having left atrial thrombus (LATH) or left atrial spontaneous echo contrast (LASEC) by transesophageal echocardiography (TEE), while the ultimate predictive value of a high uric acid (UA) level on LATH/LASEC remained obscure.
We searched the PubMed and Cochrane clinical trials databases up to July 2015. Following screening the 369 initially identified studies, we analyzed six observational studies with 2381 patients.
The meta-analysis of these studies showed that an elevated serum UA level was associated with a higher likelihood of LATH/LASEC ( = 1.59, 95% 1.13-2.23, = 0.008), while significant differences exist among individual trials ( < 0.00001 and = 85%). Sensitivity analysis failed to find any heterogeneity.
An elevated UA level was associated with a higher risk of detecting a left atrial abnormality represented by LATH/LASEC.
近期的观察性研究表明，高尿酸血症患者经食管超声心动图（TEE）检查发现左心房血栓（LATH）或左心房自发显影（LASEC）的风险更高，而高尿酸（UA）水平对LATH/LASEC的最终预测价值仍不明确。
我们检索了截至2015年7月的PubMed和Cochrane临床试验数据库。在筛选了最初识别出的369项研究后，我们分析了6项包含2381例患者的观察性研究。
这些研究的荟萃分析表明，血清尿酸水平升高与LATH/LASEC的可能性增加相关（比值比=1.59，95%置信区间1.13 - 2.23，P = 0.008），而各试验之间存在显著差异（I²<0.00001，异质性检验P = 85%）。敏感性分析未发现任何异质性。
尿酸水平升高与检测到以LATH/LASEC为代表的左心房异常的较高风险相关。
