Gao Zheng, Shi Hekai, Xu Wei, Guan Zhengzhao, Su Xiuxiu, Guo Nuojin, Ma Huijie
Department of Physiology, Hebei Medical University, Shijiazhuang, China.
Department of First Affiliated Hospital of Hebei Medical University, Shijiazhuang, China.
Int J Endocrinol. 2022 Aug 21;2022:8172639. doi: 10.1155/2022/8172639. eCollection 2022.
Association between hyperuricemia (HUA) and atrial fibrillation (AF) remains unclear. We reviewed clinical evidence and aimed to determine whether hyperuricemia leads to a high risk of atrial fibrillation. Most studies were identified through databases online. Keywords used in literature search were hyperuricemia, atrial fibrillation, metabolic disorder, endocrine disorder, or uric acid. Three studies were provided by the authors. Literature search was performed without any data or language restriction. Observational studies, including cohort studies and cross-sectional studies, were used. Study type should be clearly defined. Cross-sectional studies should clearly introduce the sources of epidemiological data. Studies were excluded if with too many complications unrelated to AF enrolled. Data were independently extracted by three individuals. Data synthesis was conducted by R version 4.1.2. Prevalence of atrial fibrillation was the main outcome. Results of meta-analysis were presented as risk ratio (RR) for different prevalence of AF between individuals with and without HUA. All data included were obtained after follow-up work is completed. Data from 608,810 participants showed that patients with hyperuricemia were easier to suffer from atrial fibrillation (RR, 2.42; 95% CI, 1.24-3.03). And the meta-regressions suggested growth of linear proportion between the ratio of current drinkers and hyperuricemia (QM = 41.0069, < 0.001). Subgroup analyses demonstrated consistent results in different countries. And design of the observational studies brought heterogeneity, but no uncertainties. Patients with hyperuricemia were easier to suffer from atrial fibrillation. Treatment of hyperuricemia or gout may bring potential benefits for AF patients.
高尿酸血症（HUA）与心房颤动（AF）之间的关联仍不明确。我们回顾了临床证据，旨在确定高尿酸血症是否会导致心房颤动的高风险。大多数研究是通过在线数据库确定的。文献检索中使用的关键词为高尿酸血症、心房颤动、代谢紊乱、内分泌紊乱或尿酸。作者提供了三项研究。文献检索不受任何数据或语言限制。使用了观察性研究，包括队列研究和横断面研究。研究类型应明确定义。横断面研究应清楚介绍流行病学数据的来源。如果纳入了太多与心房颤动无关的并发症的研究，则将其排除。数据由三个人独立提取。数据合成使用R 4.1.2版本进行。心房颤动的患病率是主要结果。荟萃分析的结果以患有和未患有高尿酸血症的个体之间不同心房颤动患病率的风险比（RR）表示。所有纳入的数据均在随访工作完成后获得。来自608,810名参与者的数据表明，高尿酸血症患者更容易患心房颤动（RR，2.42；95%CI，1.24 - 3.03）。并且荟萃回归表明当前饮酒者比例与高尿酸血症之间呈线性比例增长（QM = 41.0069，P < 0.001）。亚组分析在不同国家显示出一致的结果。观察性研究的设计带来了异质性，但没有不确定性。高尿酸血症患者更容易患心房颤动。高尿酸血症或痛风的治疗可能会给心房颤动患者带来潜在益处。
