Yu Shuang-Ni, Ma Yi-Hui, Zhao Wu-Gan, Jin Xiang-Lan, Yang Hai-Yan, Liu Ping-Ping, Chen Jie
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing 100730, China.
Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Chronic Dis Transl Med. 2016 Dec 22;2(4):215-222. doi: 10.1016/j.cdtm.2016.11.012. eCollection 2016 Dec.
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection of -driven PDAC. Here, we summarize our studies and review current reports on research investigating -related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC.
胰腺导管腺癌（PDAC）是一种致命疾病，总体预后较差。然而，在疾病早期进行根治性切除可显著提高生存率，这凸显了早期筛查和检测的重要性。对非编码RNA的研究，主要是微小RNA（miRNA）和长链非编码RNA（lncRNA），为驱动型PDAC的早期检测策略提供了重要见解。在此，我们总结我们的研究，并回顾当前关于研究相关miRNA和lncRNA的报告，强调它们在PDAC中的异常表达、机制、致癌作用以及预后和预测能力。
