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症状性多发性硬化症治疗的新进展:第2部分——步态障碍与痉挛

[What is new in symptomatic MS treatment: Part 2-gait disorder and spasticity].

作者信息

Henze T, Feneberg W, Flachenecker P, Seidel D, Albrecht H, Starck M, Meuth S G

机构信息

Praxisgemeinschaft für Neurologie, Psychiatrie, Psychotherapie, Günzstr. 1, 93059, Regensburg, Deutschland.

Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke gemeinnützige GmbH, Berg, Deutschland.

出版信息

Nervenarzt. 2017 Dec;88(12):1428-1434. doi: 10.1007/s00115-017-0439-3.

DOI:10.1007/s00115-017-0439-3
PMID:29063259
Abstract

The symptomatic treatment of multiple sclerosis (MS) nowadays is of similar importance as immunotherapy within a comprehensive concept of therapy of this chronic disease, since it contributes considerably to the reduction of disabilities in activities of daily living as well as social and occupational life. Moreover, symptomatic treatment is of great importance for amelioration of quality of life. Since our last survey of symptomatic MS treatment in 2004 and publication of the guidelines of the German Neurological Society and the Klinisches Kompetenznetz Multiple Sklerose (KKN‑MS) in 2014 several developments within the topics of mobility, bladder and sexual function, vision, fatigue, cognition and rehabilitation took place. These new findings together with further aspects of disease measures and overall treatment strategies of the respective symptoms, as well as treatment goals are introduced in a series of six individual contributions. Here, the symptoms of gait disorders and spasticity will be discussed.

摘要

在多发性硬化症(MS)这种慢性病的综合治疗理念中,对症治疗如今与免疫治疗具有同等重要性,因为它对减少日常生活活动以及社交和职业生活中的残疾状况有很大帮助。此外,对症治疗对于改善生活质量也非常重要。自我们2004年上次对MS对症治疗进行调查以及2014年德国神经学会和多发性硬化症临床能力网络(KKN-MS)发布指南以来,在 mobility、膀胱和性功能、视力、疲劳、认知及康复等主题方面有了一些进展。这些新发现连同疾病措施的其他方面以及各症状的整体治疗策略和治疗目标在一系列六篇独立稿件中进行了介绍。在此,将讨论步态障碍和痉挛的症状。

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Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper.多发性硬化痉挛的药物治疗:系统评价和共识文件。
Mult Scler. 2016 Oct;22(11):1386-1396. doi: 10.1177/1352458516643600. Epub 2016 May 19.
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Efficacy and safety of cannabinoid oromucosal spray for multiple sclerosis spasticity.大麻素口腔黏膜喷雾剂治疗多发性硬化痉挛的疗效与安全性。
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四氢大麻酚:大麻二酚观察性研究数据:耐药性多发性硬化痉挛及相关症状的演变
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