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症状性多发性硬化症治疗的新进展:第5部分 - 疲劳

[New aspects of symptomatic MS treatment: Part 5 - fatigue].

作者信息

Henze T, Feneberg W, Flachenecker P, Seidel D, Albrecht H, Starck M, Meuth S G

机构信息

Praxisgemeinschaft für Neurologie, Psychiatrie, Psychotherapie, Günzstr. 1, 93059, Regensburg, Deutschland.

Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke gemeinnützige GmbH, Berg, Deutschland.

出版信息

Nervenarzt. 2018 Apr;89(4):446-452. doi: 10.1007/s00115-017-0442-8.

DOI:10.1007/s00115-017-0442-8
PMID:29079869
Abstract

The symptomatic treatment of multiple sclerosis (MS) is nowadays of similar importance as immunotherapy within a comprehensive treatment concept of this chronic disease. It makes a considerable contribution to the reduction of disabilities in activities of daily living as well as social and occupational life. Moreover, symptomatic treatment is of great importance for amelioration of the quality of life. Since our last survey of symptomatic MS treatment in 2004 and publication of the guidelines of the German Neurological Society and the Clinical Competence Network Multiple Sclerosis (Klinisches Kompetenznetz Multiple Sklerose, KKN-MS) in 2014 several developments within the topics of mobility, bladder and sexual function, vision, fatigue, cognition and rehabilitation have taken place. These new findings together with further aspects of disease measurement methods and overall treatment strategies of the respective symptoms as well as treatment goals are introduced in a series of 6 individual contributions. In this article the symptom of fatigue is discussed.

摘要

在多发性硬化症(MS)的综合治疗理念中,对症治疗如今与免疫疗法具有同等重要性。它对减少日常生活活动以及社交和职业生活中的残疾状况做出了相当大的贡献。此外,对症治疗对于改善生活质量也至关重要。自我们上次在2004年对MS对症治疗进行调查以及德国神经病学学会和多发性硬化症临床能力网络(KKN-MS)在2014年发布指南以来,在 mobility、膀胱和性功能、视力、疲劳、认知及康复等主题方面有了多项进展。这些新发现连同疾病测量方法的其他方面、各个症状的整体治疗策略以及治疗目标在一系列6篇独立稿件中进行了介绍。本文讨论疲劳症状。

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[New aspects of symptomatic MS treatment: Part 5 - fatigue].症状性多发性硬化症治疗的新进展:第5部分 - 疲劳
Nervenarzt. 2018 Apr;89(4):446-452. doi: 10.1007/s00115-017-0442-8.
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[New aspects of symptomatic MS treatment: Part 6 - cognitive dysfunction and rehabilitation].症状性多发性硬化症治疗的新进展:第6部分 - 认知功能障碍与康复
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Comparing two relaxation procedures to ease fatigue in multiple sclerosis: a single-blind randomized controlled trial.比较两种缓解多发性硬化症疲劳的放松疗法:一项单盲随机对照试验。
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本文引用的文献

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Exercise therapy for fatigue in multiple sclerosis.多发性硬化症疲劳的运动疗法
Cochrane Database Syst Rev. 2015 Sep 11;2015(9):CD009956. doi: 10.1002/14651858.CD009956.pub2.
2
Pharmacological treatments for fatigue associated with palliative care.姑息治疗相关疲劳的药物治疗。
Cochrane Database Syst Rev. 2015 May 30;2015(5):CD006788. doi: 10.1002/14651858.CD006788.pub3.
3
Yoga therapy and ambulatory multiple sclerosis Assessment of gait analysis parameters, fatigue and balance.瑜伽疗法与非卧床多发性硬化症:步态分析参数、疲劳及平衡的评估
J Bodyw Mov Ther. 2015 Jan;19(1):72-81. doi: 10.1016/j.jbmt.2014.04.004. Epub 2014 Apr 16.
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Effect of Alfacalcidol on multiple sclerosis-related fatigue: A randomized, double-blind placebo-controlled study.阿法骨化醇对多发性硬化症相关性疲劳的影响:一项随机、双盲、安慰剂对照研究。
Mult Scler. 2015 May;21(6):767-75. doi: 10.1177/1352458514554053. Epub 2014 Oct 24.
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Management of fatigue in persons with multiple sclerosis.多发性硬化症患者疲劳的管理。
Front Neurol. 2014 Sep 15;5:177. doi: 10.3389/fneur.2014.00177. eCollection 2014.
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Meta-analysis of three different types of fatigue management interventions for people with multiple sclerosis: exercise, education, and medication.针对多发性硬化症患者的三种不同类型疲劳管理干预措施的荟萃分析:运动、教育和药物治疗。
Mult Scler Int. 2014;2014:798285. doi: 10.1155/2014/798285. Epub 2014 May 14.
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Objective assessment of motor fatigue in multiple sclerosis: the Fatigue index Kliniken Schmieder (FKS).多发性硬化症运动疲劳的客观评估:施密德诊所疲劳指数(FKS)
J Neurol. 2014 Sep;261(9):1752-62. doi: 10.1007/s00415-014-7415-7. Epub 2014 Jun 22.
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One year follow-up of a pragmatic multi-centre randomised controlled trial of a group-based fatigue management programme (FACETS) for people with multiple sclerosis.一项针对多发性硬化症患者的基于小组的疲劳管理计划(FACETS)的实用多中心随机对照试验的一年随访。
BMC Neurol. 2014 May 19;14:109. doi: 10.1186/1471-2377-14-109.
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Mindfulness based interventions in multiple sclerosis--a systematic review.基于正念的多发性硬化症干预措施——系统评价。
BMC Neurol. 2014 Jan 17;14:15. doi: 10.1186/1471-2377-14-15.
10
Evaluating the effects of amantadin, modafinil and acetyl-L-carnitine on fatigue in multiple sclerosis--result of a pilot randomized, blind study.评估金刚烷胺、莫达非尼和乙酰左旋肉碱对多发性硬化症疲劳的影响——一项初步随机双盲研究的结果。
Clin Neurol Neurosurg. 2013 Dec;115 Suppl 1:S86-9. doi: 10.1016/j.clineuro.2013.09.029.