Maekawa Tomoko, Sato Noriko, Ota Miho, Sugiyama Atsuhiko, Sone Daichi, Enokizono Mikako, Kimura Yukio, Mukai Youhei, Murata Miho, Takano Harumasa, Imabayashi Etsuko, Matsuda Hiroshi, Kunimatsu Akira, Abe Osamu
Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
Department of Radiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Jpn J Radiol. 2017 Dec;35(12):755-759. doi: 10.1007/s11604-017-0694-z. Epub 2017 Oct 23.
Parkinson's disease (PD) is caused by a selective degeneration of dopamine neurons. The relationship between dopamine transporter (DAT) density and gray matter volume has been unclear. Here we investigated the voxelwise correlation between gray matter volume and DAT binding measured by I-N-ω-fluoropropyl-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane (I-FP-CIT) single-photon emission computed tomography (SPECT; DaTscan™ imaging) in PD.
Thirty-one male patients with PD were examined with MRI and DaTscan. To measure nigrostriatal dopaminergic degeneration in PD, the specific binding ratio (SBR) of the striatum was obtained by DaTscan. Voxel-based morphometry (VBM) of 3D T1-weighted images was used to evaluate the relationships between the regional gray matter volume and the SBR in the striatum.
There were significant positive correlations between the SBR and the gray matter volume in the right pulvinar and posterior middle temporal gyrus and a trend level in the left pulvinar, all of which are associated with the second visual pathway.
The nigrostriatal dopaminergic degeneration might affect the secondary visual pathway, leading to visual dysfunctions in PD.
帕金森病（PD）由多巴胺能神经元的选择性变性引起。多巴胺转运体（DAT）密度与灰质体积之间的关系尚不清楚。在此，我们研究了PD患者中通过I-N-ω-氟丙基-2β-羧基甲氧基-3β-（4-碘苯基）去甲托烷（I-FP-CIT）单光子发射计算机断层扫描（SPECT；DaTscan™成像）测量的灰质体积与DAT结合之间的体素相关性。
对31例男性PD患者进行了MRI和DaTscan检查。为测量PD患者黑质纹状体多巴胺能变性，通过DaTscan获得纹状体的特异性结合率（SBR）。使用基于体素的形态学分析（VBM）对三维T1加权图像进行分析，以评估区域灰质体积与纹状体SBR之间的关系。
SBR与右侧丘脑枕和颞中回后部的灰质体积之间存在显著正相关，左侧丘脑枕存在趋势水平的相关性，所有这些均与第二视觉通路相关。
黑质纹状体多巴胺能变性可能影响第二视觉通路，导致PD患者出现视觉功能障碍。
