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从流苏石豆兰地上部分分离得到的两种新芪类化合物。

Two new stilbenoids from aerial parts of Flickingeria fimbriata.

作者信息

Chen Dan-Na, Wu Ya-Ping, Chen Yue-Juan, Liu Wen-Jian, Wang Jing-Xian, He Feng, Jiang Lin

机构信息

a School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , China.

出版信息

J Asian Nat Prod Res. 2019 Feb;21(2):117-122. doi: 10.1080/10286020.2017.1392942. Epub 2017 Oct 24.

Abstract

Two new stilbenoids, named 2,3 -dimethoxyl-7-hydroxyl-1,4-phenanthrenedione (1) and 2-methoxyl-3-methyl-7-hydroxyl-9,10-dihydro-1,4-phenanthrenedione (2), together with two known stilbenoids including densiflorol B (3) and ephemeranthoquinone (4), were isolated from aerial parts of Flickingeria fimbriata (Bl.) Hawkes. The structures of two new compounds were elucidated by extensive spectroscopic analysis, including HRESIMS, H and C NMR, DEPT, HMBC, COSY, HMQC, NOESY. All the compounds were obtained from this genus for the first time. In addition, they all exhibited moderate cytotoxic activities against HepG2 cell lines.

摘要

从毛叶金石斛(Flickingeria fimbriata (Bl.) Hawkes)的地上部分分离得到了两种新的芪类化合物,分别命名为2,3 -二甲氧基-7-羟基-1,4-菲醌(1)和2-甲氧基-3-甲基-7-羟基-9,10-二氢-1,4-菲醌(2),以及两种已知的芪类化合物,包括密花石斛酚B(3)和短茎石斛醌(4)。通过广泛的光谱分析,包括高分辨电喷雾电离质谱(HRESIMS)、氢核磁共振(H NMR)、碳核磁共振(C NMR)、无畸变极化转移增强法(DEPT)、异核多键相关谱(HMBC)、同核化学位移相关谱(COSY)、异核单量子相关谱(HMQC)和核Overhauser效应光谱(NOESY),阐明了这两种新化合物的结构。所有化合物均首次从该属植物中获得。此外,它们对肝癌细胞系(HepG2)均表现出中等程度的细胞毒性活性。

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