Chen Dan-Na, Wu Ya-Ping, Chen Yue-Juan, Liu Wen-Jian, Wang Jing-Xian, He Feng, Jiang Lin
a School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , China.
J Asian Nat Prod Res. 2019 Feb;21(2):117-122. doi: 10.1080/10286020.2017.1392942. Epub 2017 Oct 24.
Two new stilbenoids, named 2,3 -dimethoxyl-7-hydroxyl-1,4-phenanthrenedione (1) and 2-methoxyl-3-methyl-7-hydroxyl-9,10-dihydro-1,4-phenanthrenedione (2), together with two known stilbenoids including densiflorol B (3) and ephemeranthoquinone (4), were isolated from aerial parts of Flickingeria fimbriata (Bl.) Hawkes. The structures of two new compounds were elucidated by extensive spectroscopic analysis, including HRESIMS, H and C NMR, DEPT, HMBC, COSY, HMQC, NOESY. All the compounds were obtained from this genus for the first time. In addition, they all exhibited moderate cytotoxic activities against HepG2 cell lines.
从毛叶金石斛（Flickingeria fimbriata (Bl.) Hawkes）的地上部分分离得到了两种新的芪类化合物，分别命名为2,3 -二甲氧基-7-羟基-1,4-菲醌（1）和2-甲氧基-3-甲基-7-羟基-9,10-二氢-1,4-菲醌（2），以及两种已知的芪类化合物，包括密花石斛酚B（3）和短茎石斛醌（4）。通过广泛的光谱分析，包括高分辨电喷雾电离质谱（HRESIMS）、氢核磁共振（H NMR）、碳核磁共振（C NMR）、无畸变极化转移增强法（DEPT）、异核多键相关谱（HMBC）、同核化学位移相关谱（COSY）、异核单量子相关谱（HMQC）和核Overhauser效应光谱（NOESY），阐明了这两种新化合物的结构。所有化合物均首次从该属植物中获得。此外，它们对肝癌细胞系（HepG2）均表现出中等程度的细胞毒性活性。
