从石斛中鉴定出两种新菲并研究其对人下咽鳞癌细胞（FaDu）的细胞毒性。
Identification of Two New Phenanthrenes from Dendrobii Herba and Their Cytotoxicity towards Human Hypopharynx Squamous Carcinoma Cell (FaDu).
机构信息
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do 56212, Korea.
College of Pharmacy, Chonnam National University, Gwangju 61186, Korea.
出版信息
Molecules. 2019 Jun 25;24(12):2339. doi: 10.3390/molecules24122339.
Two new phenanthrenes, (1,2)-1,7-hydroxy-2,8-methoxy-2,3-dihydrophenanthrene-4(1)-one () and 2,7-dihydroxy-phenanthrene-1,4-dione (), were isolated from the ethyl acetate-soluble fraction of Dendrobii Herba, together with seven known phenanthrenes (-), two bibenzyls (-), and a lignan (). Structures of and were elucidated by analyzing one-dimensional (1D) and two-dimensional (2D)-NMR and High-resolution electrospray ionization mass spectra (HR-ESI-MS) data. The absolute configuration of compound was confirmed by the circular dichroism (CD) spectroscopic method. In cytotoxicity assay using FaDu human hypopharynx squamous carcinoma cell line, compounds -, , , and showed activities, with IC values that ranged from 2.55 to 17.70 μM.
从铁皮石斛的乙酸乙酯可溶部分中分离得到了两个新的菲并[9,10-d]呋喃酮类化合物，(1,2)-1,7-二羟基-2,8-甲氧基-2,3-二氢菲并[4,1-b]呋喃-4(1H)-酮()和 2,7-二羟基菲-1,4-二酮()，以及七个已知的菲并[9,10-d]呋喃酮类化合物(-)、两个二苄基类化合物(-)和一个木脂素(-)。通过分析一维(1D)和二维(2D)-NMR 以及高分辨电喷雾电离质谱(HR-ESI-MS)数据，确定了化合物和的结构。通过圆二色光谱(CD)光谱法确定了化合物的绝对构型。在使用 FaDu 人下咽鳞癌细胞系的细胞毒性测定中，化合物-、-、-、和-表现出活性，IC 值范围为 2.55 至 17.70 μM。
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