School of Life Sciences, Guangzhou University, Guangzhou 510006, People's Republic of China; Program of Natural Product Medicinal Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China.
Program of Natural Product Medicinal Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
Fitoterapia. 2019 Apr;134:264-269. doi: 10.1016/j.fitote.2019.02.025. Epub 2019 Feb 27.
Five new compounds including two stilbenes, designated thujasutchins A (1) and B (2), two phenolic compounds namely thujasutchins C (3) and D (4), as well as one sesquiterpene thujasutchin E (5), were isolated from the 95% ethanolic extract from the trunks and roots of Thuja sutchuenensis. Their structures were determined by means of extensively spectroscopic analysis including UV, IR, HRESIMS, H and C NMR (COSY, HSQC, HMBC). Moreover, compounds 1, 3-5 were evaluated for in vitro cytotoxic activities against SF-268, MCF-7, HepG-2, and A549 tumor cell lines.
从柏木 Thuja sutchuenensis 的树干和根部的 95%乙醇提取物中分离得到了 5 种新化合物，包括 2 种二苯乙烯类化合物，分别命名为 thujasutchins A（1）和 B（2），2 种酚类化合物，即 thujasutchins C（3）和 D（4），以及一种倍半萜类化合物 thujasutchin E（5）。通过广泛的光谱分析，包括 UV、IR、HRESIMS、H 和 C NMR（COSY、HSQC、HMBC），确定了它们的结构。此外，还评估了化合物 1、3-5 对 SF-268、MCF-7、HepG-2 和 A549 肿瘤细胞系的体外细胞毒性活性。
