Smith Shane D B, Erdag Gulsun, Cuda Jonathan D, Rangwala Sophie, Girardi Nicholas, Bibee Kristin, Orens Jonathan B, Prono Maria Dioverti, Toptan Tuna, Loss Manisha J
Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Transpl Infect Dis. 2018 Feb;20(1). doi: 10.1111/tid.12793. Epub 2017 Nov 26.
Human polyomavirus-7-associated rash and pruritus (PVARP) is a chronic superficial viral skin infection, which primarily impacts immunocompromised individuals. We report on a case of PVARP in a lung transplant recipient. Our patient developed symptoms 13 years after being on his immunosuppressive regimen, with an insidious course of progressive gray lichenification with marked islands of sparing and quality of life-altering pruritus. Treatment for PVARP is not established; however, topical cidofovir combined with immunomodulation may offer sustained therapeutic benefit.
人多瘤病毒7型相关皮疹和瘙痒症（PVARP）是一种慢性浅表性病毒性皮肤感染，主要影响免疫功能低下的个体。我们报告一例肺移植受者的PVARP病例。我们的患者在接受免疫抑制治疗13年后出现症状，病程隐匿，表现为进行性灰色苔藓化，有明显的 spared岛，伴有改变生活质量的瘙痒。PVARP的治疗方法尚未确立；然而，局部使用西多福韦联合免疫调节可能会带来持续的治疗益处。
