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在光化性角化病活检标本中检测 MCPyV、HPyV6、HPyV7 和 TSPyV 的流行率。

Prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in Actinic Keratosis Biopsy Specimens.

机构信息

IRCSS San Raffaele Roma, Microbiology of Chronic Neuro-Degenerative Pathologies, 00163 Rome, Italy.

Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, 00185 Rome, Italy.

出版信息

Viruses. 2022 Feb 18;14(2):427. doi: 10.3390/v14020427.

DOI:10.3390/v14020427
PMID:35216020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8876850/
Abstract

To date, 14 human polyomaviruses (HPyVs) have been identified using high-throughput technologies. Among them, MCPyV, HPyV6, HPyV7 and TSPyV present a skin tropism, but a causal role in skin diseases has been established only for MCPyV as a causative agent of Merkel cell carcinoma (MCC) and TSPyV as an etiological agent of Trichodysplasia Spinulosa (TS). In the search for a possible role for cutaneous HPyVs in the development of skin malignant lesions, we investigated the prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in actinic keratosis (AK), a premalignant skin lesion that has the potential to progress towards a squamous cell carcinoma (SCC). One skin lesion and one non-lesion skin from nine affected individuals were analyzed by qualitative PCR. MCPyV was detected in 9 out of 9 lesion biopsies and 6 out of 8 non-lesion biopsies. HPyV6 was detected only in healthy skin, while HPyV7 and TSPyV were not detected in any skin sample. These findings argue against a possible role of cutaneous HPyVs in AK. However, considering the small sample size analyzed, a definitive conclusion cannot be drawn. Longitudinal studies on large cohorts are warranted.

摘要

迄今为止，已有 14 种人类多瘤病毒（HPyV）通过高通量技术被鉴定出来。其中，MCPyV、HPyV6、HPyV7 和 TSPyV 具有皮肤趋向性，但只有 MCPyV 被确定为 Merkel 细胞癌（MCC）的病原体，TSPyV 被确定为 Trichodysplasia Spinulosa（TS）的病因，与皮肤疾病有因果关系。在寻找皮肤 HPyV 可能在皮肤恶性病变发展中的作用时，我们调查了多瘤病毒 MCPyV、HPyV6、HPyV7 和 TSPyV 在光化性角化病（AK）中的流行情况，AK 是一种具有发展为鳞状细胞癌（SCC）潜能的癌前皮肤病变。通过定性 PCR 分析了 9 名受影响个体的 1 个皮肤病变和 1 个非病变皮肤。在 9 个病变活检中均检测到了 MCPyV，在 8 个非病变活检中有 6 个检测到了 MCPyV。仅在健康皮肤中检测到 HPyV6，而在任何皮肤样本中均未检测到 HPyV7 和 TSPyV。这些发现表明皮肤 HPyV 可能与 AK 无关。然而，鉴于分析的样本量较小，不能得出明确的结论。需要对大量患者进行纵向研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0dd/8876850/8ef32407780f/viruses-14-00427-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0dd/8876850/2c699efe3f74/viruses-14-00427-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0dd/8876850/8ef32407780f/viruses-14-00427-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0dd/8876850/2c699efe3f74/viruses-14-00427-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0dd/8876850/8ef32407780f/viruses-14-00427-g002.jpg

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