From the *Columbia University College of Physicians & Surgeons; and †Department of Dermatology, Columbia University Medical Center, New York, NY.
Dermatitis. 2017 Nov/Dec;28(6):342-345. doi: 10.1097/DER.0000000000000327.
Alkyl glucoside surfactants, present in many cosmetic products, can cause allergic contact dermatitis. Decyl glucoside has been part of the North American Contact Dermatitis Group standard allergen panel since 2009.
This study aimed to identify rates and relevance of positive patch test reactions to decyl and lauryl glucosides and to determine how well one of these glucosides screens for contact allergic reactions to the other.
A retrospective analysis was performed on 897 patients suspected of having a cosmetic-related dermatitis and patch tested with both decyl and lauryl glucosides between 2009 and 2016.
Forty-eight patients (5%) had positive reactions to decyl glucoside and/or lauryl glucoside. Among the alkyl glucoside-allergic patients, 65% had positive reactions to both decyl and lauryl glucosides. In 41% of cases, reactions were of definite or probable relevance. In approximately 55% of cases, reactions were of possible relevance.
Sixty-five percent of glucoside-allergic patients exhibited co-reactions to decyl and lauryl glucosides. Thus, neither glucoside is an adequate screen for allergy to the other. Given that these reactions are often relevant, clinicians should patch test with decyl, lauryl, and other alkyl glucosides in cases of suspected cosmetic allergy.
烷基糖苷表面活性剂存在于许多化妆品中，可引起过敏性接触性皮炎。自 2009 年以来，癸基糖苷已成为北美接触性皮炎组标准变应原组合的一部分。
本研究旨在确定对癸基和月桂基葡萄糖苷的阳性斑贴试验反应率和相关性，并确定其中一种葡萄糖苷对另一种葡萄糖苷的接触过敏反应的筛查效果如何。
对 2009 年至 2016 年间怀疑患有与化妆品相关的皮炎并接受癸基和月桂基葡萄糖苷斑贴试验的 897 例患者进行了回顾性分析。
48 例（5%）对癸基葡萄糖苷和/或月桂基葡萄糖苷有阳性反应。在烷基糖苷过敏患者中，65%对癸基和月桂基葡萄糖苷均有阳性反应。在 41%的病例中，反应具有明确或可能的相关性。在大约 55%的情况下，反应具有可能的相关性。
65%的葡萄糖苷过敏患者对癸基和月桂基葡萄糖苷表现出共同反应。因此，两种葡萄糖苷都不能作为对另一种葡萄糖苷过敏的充分筛查。鉴于这些反应通常具有相关性，临床医生应在怀疑化妆品过敏的情况下用癸基、月桂基和其他烷基糖苷进行斑贴试验。
