Department of Dermatology, Chapel Allerton Hospital, Leeds, UK.
Department of Dermatology, Great Ormond Street Hospital for Children, London, UK.
Contact Dermatitis. 2019 May;80(5):286-290. doi: 10.1111/cod.13186. Epub 2018 Dec 21.
Alkyl glucosides contitute a family of mild surfactants that are increasingly being used in a wide range of cosmetics and household products. Contact allergy to alkyl glucosides may be more frequent than previously suspected, especially in atopic patients.
To investigate the frequency of contact allergy to alkyl glucosides, and to identify concomitant reactivity.
We retrospectively reviewed all cases of suspected allergic contact dermatitis (ACD) in which patients were patch tested with either a cosmetic series that includes five alkyl glucosides (decyl glucoside, lauryl glucoside, coco glucoside, cetearyl glucoside, and caprylyl/capryl glucoside) or a specific alkyl glucoside series from November 2013 to April 2017 in two UK centres.
A total of 5775 patients were patch tested across the two centres. Twenty-nine (1.04%) of the 2796 patients tested with the cosmetic/alkyl glucoside series had a positive patch test reaction to at least one of the alkyl glucosides. Twenty-three (79.3%) patients were sensitized to multiple alkyl glucosides; 21 patients (72.4%) were female. The mean age was 43.5 years. Twelve patients (41.4%) had a background of atopic dermatitis.
The prevalence of alkyl glucoside-induced ACD is relatively high, and there are frequent concomitant reactions between different alkyl glucosides. We recommend the inclusion of alkyl glucosides in all cosmetic series.
烷基糖苷是一类温和的表面活性剂，其应用范围越来越广泛，涉及各种化妆品和家用产品。人们对烷基糖苷的接触过敏可能比之前认为的更为常见，尤其是特应性患者。
研究接触烷基糖苷引起的过敏反应的频率，并确定同时发生的反应。
我们回顾性分析了 2013 年 11 月至 2017 年 4 月在英国两个中心，使用包括五种烷基糖苷（癸基葡糖苷、月桂基葡糖苷、椰油基葡糖苷、鲸蜡硬脂基葡糖苷和辛基/癸基葡糖苷）的化妆品系列或特定的烷基糖苷系列进行斑贴试验的疑似过敏性接触性皮炎（ACD）患者的所有病例。
在两个中心共有 5775 例患者接受了斑贴试验。2796 例接受化妆品/烷基糖苷系列斑贴试验的患者中，有 29 例（1.04%）至少对一种烷基糖苷的斑贴试验呈阳性反应。23 例（79.3%）患者对多种烷基糖苷敏感；21 例（72.4%）为女性。平均年龄为 43.5 岁。12 例（41.4%）患者有特应性皮炎病史。
烷基糖苷诱导的 ACD 的患病率相对较高，不同烷基糖苷之间常同时发生反应。我们建议在所有化妆品系列中加入烷基糖苷。
