糖苷斑贴试验：2009-2018 年北美接触性皮炎组的经验。

Patch testing with glucosides: The North American Contact Dermatitis Group experience, 2009-2018.

机构信息

Department of Dermatology, Park Nicollet/Health Partners Health Services, Minneapolis, Minnesota; Department of Dermatology, University of Minnesota, Minneapolis, Minnesota; Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota.

Department of Dermatology, Park Nicollet/Health Partners Health Services, Minneapolis, Minnesota; Warren Alpert Medical School of Brown University, Providence, Rhode Island.

出版信息

J Am Acad Dermatol. 2022 Nov;87(5):1033-1041. doi: 10.1016/j.jaad.2022.04.058. Epub 2022 May 10.

DOI:10.1016/j.jaad.2022.04.058

PMID:35551968

Abstract

BACKGROUND

Alkyl glucosides are nonionic surfactants that are increasingly used in personal care products.

OBJECTIVE

To characterize positive patch test reactions to decyl glucoside (5% petrolatum, tested 2009-2018) and lauryl glucoside (3% petrolatum, tested 2017-2018).

METHODS

Retrospective analysis of patients tested by the North American Contact Dermatitis Group.

RESULTS

Of 24,097 patients patch tested to decyl and/or lauryl glucoside, 470 (2.0%) had positive reactions. Compared with glucoside-negative patients, glucoside-positive patients had higher odds of occupational skin disease (13.4% vs 10.1%; P = .0207), history of hay fever (38.5% vs 31.6%; P = .0014), atopic dermatitis (39.0% vs 28.6%; P < .0001), and/or asthma (21.8% vs 16.5%; P = .0023). Most glucoside reactions (83.9%) were currently relevant. The most common source was personal care products (63.0%), especially hair products (16.5%) and skin cleansers (15.2%). Of 4933 patients tested to decyl and lauryl glucoside, 134 (2.7%) were positive to 1 or both; 43.4% (43 of 99) of decyl-positive patients were also positive to lauryl glucoside and 55.1% (43/78) of lauryl glucoside patients were also positive to decyl glucoside.

LIMITATIONS

The cohort predominantly reflects a referral population, and follow-up after testing was not captured.

CONCLUSION

Glucoside positivity occurred in 2.0% of the tested patients. Reactions were often clinically relevant and linked to personal care products. Cross-reactivity was >40%.

摘要

背景

烷基糖苷是越来越多地应用于个人护理产品的非离子表面活性剂。

目的

描述癸基葡萄糖苷（5%凡士林，2009-2018 年检测）和月桂基葡萄糖苷（3%凡士林，2017-2018 年检测）阳性斑贴试验反应的特征。

方法

回顾性分析北美接触性皮炎组检测的患者。

结果

在 24097 例接受癸基和/或月桂基葡萄糖苷斑贴试验的患者中，有 470 例（2.0%）出现阳性反应。与糖苷阴性患者相比，糖苷阳性患者职业性皮肤病的可能性更高（13.4%对 10.1%；P=0.0207）、花粉症病史（38.5%对 31.6%；P=0.0014）、特应性皮炎（39.0%对 28.6%；P<0.0001）和/或哮喘（21.8%对 16.5%；P=0.0023）。大多数糖苷反应（83.9%）目前与接触相关。最常见的来源是个人护理产品（63.0%），尤其是头发产品（16.5%）和皮肤清洁剂（15.2%）。在 4933 例接受癸基和月桂基葡萄糖苷检测的患者中，有 134 例（2.7%）对 1 种或 2 种均为阳性；43.4%（43/99）的癸基阳性患者也对月桂基葡萄糖苷阳性，55.1%（43/78）的月桂基葡萄糖苷阳性患者也对癸基葡萄糖苷阳性。