Division of Epidemiology & Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Br J Cancer. 2018 Jan;118(1):121-126. doi: 10.1038/bjc.2017.358. Epub 2017 Oct 24.
Studies of family history of cancer in paediatric germ cell tumours (GCTs) are few, and none has had sufficient sample size to specifically evaluate family history of GCT.
We utilised family history data from a paediatric GCT study to calculate standardised incidence ratios (SIR) for GCT and other cancers using age- and sex-specific incidence rates from the SEER Program.
This analysis included 7998 relatives of paediatric GCT probands. We observed a higher number of GCT cases than expected in male and female relatives of probands (SIR=2.38, 95% CI 1.25, 3.51 for males; SIR=14.3, 95% CI 0.29, 28.4 for females). Further, we observed a particularly strong SIR for relatives of probands with intracranial GCT (SIR=8.07, 95% CI 3.51, 12.6). The SIR for relatives of probands with ovarian GCT was also elevated but did not reach statistical significance (SIR 4.35, 95% CI 0-9.27). Other notable associations include elevated SIRs for melanoma in male relatives and reduced SIRs for lymphatic/haematologic malignancies in male and female relatives.
These results support the hypothesis that familial aggregation of GCT occurs in males and females.
针对儿童生殖细胞肿瘤（GCT）的家族癌症史研究较少，且没有研究具有足够的样本量来专门评估 GCT 的家族史。
我们利用儿科 GCT 研究中的家族史数据，使用 SEER 计划中的年龄和性别特异性发病率来计算 GCT 和其他癌症的标准化发病比（SIR）。
本分析包括 7998 名儿科 GCT 先证者的亲属。我们观察到先证者的男性和女性亲属中 GCT 病例数高于预期（男性 SIR=2.38，95%CI 1.25，3.51；女性 SIR=14.3，95%CI 0.29，28.4）。此外，我们观察到颅内 GCT 先证者亲属的 SIR 特别高（SIR=8.07，95%CI 3.51，12.6）。卵巢 GCT 先证者亲属的 SIR 也升高，但未达到统计学意义（SIR 4.35，95%CI 0-9.27）。其他值得注意的关联包括男性亲属中黑色素瘤的 SIR 升高，以及男性和女性亲属中淋巴/血液恶性肿瘤的 SIR 降低。
这些结果支持 GCT 在男性和女性中存在家族聚集的假设。
