全基因组结构变异分析揭示中国猪种的遗传差异。

Yang Ruifei, Fang Suyun, Wang Jing, Zhang Chunyuan, Zhang Ran, Liu Di, Zhao Yiqiang, Hu Xiaoxiang, Li Ning

Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, P. R. China.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, P. R. China.

PLoS One. 2017 Oct 24;12(10):e0186721. doi: 10.1371/journal.pone.0186721. eCollection 2017.

Pigs have experienced long-term selections, resulting in dramatic phenotypic changes. Structural variants (SVs) are reported to exert extensive impacts on phenotypic changes. We built a high resolution and informative SV map based on high-depth sequencing data from 66 Chinese domestic and wild pigs. We inferred the SV formation mechanisms in the pig genome and used SVs as materials to perform a population-level analysis. We detected the selection signals on chromosome X for northern Chinese domestic pigs, as well as the differentiated loci across the whole genome. Analysis showed that these loci differ between southern and northern Chinese domestic pigs. Our results based on SVs provide new insights into genetic differences in Chinese pigs.

猪经历了长期的选择，导致了显著的表型变化。据报道，结构变异（SVs）对表型变化有广泛影响。我们基于66头中国家猪和野猪的高深度测序数据构建了一个高分辨率且信息丰富的SV图谱。我们推断了猪基因组中SV的形成机制，并将SV用作材料进行群体水平分析。我们检测到了中国北方家猪X染色体上的选择信号，以及全基因组中的分化位点。分析表明，这些位点在中国南方和北方家猪之间存在差异。我们基于SV的研究结果为中国猪的遗传差异提供了新的见解。