Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
Department of Pharmacy, University of Swabi, Swabi 23340, Pakistan.
Molecules. 2017 Oct 21;22(10):1699. doi: 10.3390/molecules22101699.
In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere with drug metabolism, the mode of their interaction with drug transport processes is not well described. Such interactions may result in serious undesired effects and changed drug efficacy, therefore, some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction between botanical supplements and the drug transporters is clinically significant.
在草药学中，植物补充剂通常被认为是安全的疗法，然而，植物补充剂和膳食成分会与转运和代谢过程相互作用，影响药物处置。尽管大量研究已经描述了植物补充剂会干扰药物代谢，但它们与药物转运过程相互作用的方式尚未得到很好的描述。这种相互作用可能导致严重的不良反应和药物疗效改变，因此，本文描述了一些关于植物补充剂成分与 P-糖蛋白和有机阴离子转运多肽等药物转运体之间相互作用的研究，表明植物补充剂与药物转运体之间的相互作用具有临床意义。
