Wahab Awais, Gao Kuo, Jia Caixia, Zhang Feilong, Tian Guihua, Murtaza Ghulam, Chen Jianxin
School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
Molecules. 2017 Aug 18;22(8):1329. doi: 10.3390/molecules22081329.
Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their associated complications. The clinical outcomes are affected by many factors such as sample size. This article not only presents a comprehensive review of the current advances concerning the dose, the extent of absorption, interaction and toxicity of resveratrol in human studies, but also describes its therapeutic effects against several chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer and aging and the related diseases.
白藜芦醇对健康有益，并能预防多种病理状况和与年龄相关的问题，临床前研究已证实这一点。然而，动物研究和人体研究的比较表明，这种膳食多酚无法预防代谢性疾病及其相关并发症。临床结果受许多因素影响，如样本量。本文不仅全面综述了人体研究中白藜芦醇在剂量、吸收程度、相互作用和毒性方面的当前进展，还描述了其对几种慢性疾病（如糖尿病、肥胖症、心血管疾病、癌症和衰老及相关疾病）的治疗作用。
