a The Umbilical Cord Stem Cell Research Center (UCSRC) , Tabriz University of Medical Sciences , Tabriz , Iran.
b Department of Medical Biotechnology, Faculty of Advanced Medical Sciences , Tabriz University of Medical Sciences , Tabriz , Iran.
Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1694-1707. doi: 10.1080/21691401.2017.1391820. Epub 2017 Oct 24.
The intraocular administration of the ciliary neurotrophic factor (CNTF) has been found to attenuate the photoreceptor degeneration and preserve retinal functions in the animal research models of the inherited or induced retinal disease. Studies with the aim of CNTF transfer to the posterior segment inside the eye have been directed to determine the best method for its administration. An ideal delivery method would overcome the eye drug elimination mechanisms or barriers and provide the sustained release of the CNTF into retina in the safest fashion with the minimum harm to the quality of life. This review focuses on the present state of CNTF delivery to retina, also provides an overview of available technologies and their challenges.
睫状神经营养因子（CNTF）的眼内给药已被发现可减轻遗传性或诱导性视网膜疾病动物研究模型中的光感受器变性并维持视网膜功能。旨在将 CNTF 转移到眼内后段的研究旨在确定其给药的最佳方法。理想的递药方法将克服眼部药物消除机制或屏障，并以对生活质量的最小损害以最安全的方式将 CNTF 持续递送到视网膜中。本综述重点介绍了 CNTF 递送到视网膜的现状，还概述了现有技术及其挑战。
