将第二条染色体突变定位到. 中的特定基因组区域
Mapping Second Chromosome Mutations to Defined Genomic Regions in .
作者信息
Kahsai Lily, Cook Kevin R
机构信息
Bloomington Drosophila Stock Center, Department of Biology, Indiana University, Bloomington, Indiana 47405.
Bloomington Drosophila Stock Center, Department of Biology, Indiana University, Bloomington, Indiana 47405
出版信息
G3 (Bethesda). 2018 Jan 4;8(1):9-16. doi: 10.1534/g3.117.300289.
Hundreds of stocks are currently maintained at the Bloomington Stock Center with mutations that have not been associated with sequence-defined genes. They have been preserved because they have interesting loss-of-function phenotypes. The experimental value of these mutations would be increased by tying them to specific genomic intervals so that geneticists can more easily associate them with annotated genes. Here, we report the mapping of 85 second chromosome complementation groups in the Bloomington collection to specific, small clusters of contiguous genes or individual genes in the sequenced genome. This information should prove valuable to geneticists interested in processes associated with particular phenotypes and those searching for mutations affecting specific sequence-defined genes.
目前，布鲁明顿果蝇品系中心保存着数百个具有未与序列定义基因相关联的突变的果蝇品系。它们之所以被保存下来，是因为它们具有有趣的功能丧失表型。通过将这些突变与特定的基因组区间关联起来，可以提高这些突变的实验价值，这样遗传学家就能更容易地将它们与注释基因联系起来。在这里，我们报告了布鲁明顿果蝇品系中心85个第二染色体互补群在已测序基因组中定位到特定的、相邻基因的小簇或单个基因。这一信息对于对特定表型相关过程感兴趣的遗传学家以及寻找影响特定序列定义基因的突变的遗传学家来说应该是有价值的。
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