Verratti Vittore, Ietta Francesca, Paulesu Luana, Romagnoli Roberta, Ceccarelli Ilaria, Doria Christian, Fanò Illic Giorgio, Di Giulio Camillo, Aloisi Anna M
Department of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy
Department of Life Sciences, University of Siena, Siena, Italy.
Physiol Rep. 2017 Nov;5(20). doi: 10.14814/phy2.13400.
Altitude hypoxia is often associated with impairment of human reproduction. In this study, hormones and macrophage migration inhibitory factor (MIF, a proinflammatory cytokine with key roles in human reproduction) were determined in seven regularly menstruating, lowlander native women living at sea level participating in 14 days of trekking at moderate and high altitude. Blood and saliva samples were collected from each subject at high altitude (5050 m a.s.l. [above sea level]), and at sea level before and after the expedition. Testosterone level was lowered by high altitude and was restored after the end of the expedition, while progesterone decreased significantly in all participants at the end of the expedition, although most of the participants were in the luteal phase. The salivary concentration of MIF decreased greatly at altitude, but its levels were completely restored after the return to sea level. Our findings showed high sensitivity and rapid changes in the determined parameters in response to the high-altitude hypoxic environment, particularly MIF.
高原低氧常与人类生殖功能受损有关。在本研究中，对7名居住在海平面的月经周期正常的低地女性进行了测定，她们参与了为期14天的中高海拔徒步旅行。在高海拔地区（海拔5050米）以及远征前后的海平面，采集了每位受试者的血液和唾液样本。睾酮水平在高海拔时降低，远征结束后恢复，而孕酮在远征结束时所有参与者中均显著下降，尽管大多数参与者处于黄体期。MIF的唾液浓度在海拔高度时大幅下降，但返回海平面后其水平完全恢复。我们的研究结果表明，所测定的参数对高海拔低氧具有高敏感性和快速变化，尤其是MIF。
