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女性性功能障碍:聚焦于氟班色林。

Female sexual dysfunction: a focus on flibanserin.

作者信息

Lodise Nicole M

机构信息

Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, NY, USA.

出版信息

Int J Womens Health. 2017 Oct 11;9:757-767. doi: 10.2147/IJWH.S83747. eCollection 2017.

DOI:10.2147/IJWH.S83747
PMID:29066935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5644557/
Abstract

Flibanserin is the first US Food and Drug Administration (FDA)-approved option for sexual dysfunction, specifically low sexual desire. Until recently, there were no FDA-approved medication options to assist the ~40% of women affected by female sexual dysfunction (FSD). Often, patients report feeling uncomfortable discussing sexual health, identifying a strong need for health care professionals (HCPs) to proactively reach out to patients to identify concerns and initiate a discussion about sexual health and the available treatment options. Within the (DMS-5), the criteria of female sexual interest/arousal disorder (FSIAD) are outlined, encompassing one of the most common sexual concerns, formerly in its own category defined as hypoactive sexual desire disorder (HSDD) or low sexual desire. HSDD is the absence or deficiency of sexual interest and/or desire leading to significant distress and interpersonal difficulties. HCPs offer an important service in assessing their patients and providing information about treatment considerations while ensuring patient comfort with this topic. This article provides an overview of the types and potential causes associated with FSD and the role of flibanserin in practice as a treatment option. Despite a need for additional study in diverse populations, flibanserin has demonstrated efficacy with increased female sexual function index (FSFI) total and desire domain scores in clinical studies indicating benefit in sexual desire. Common patient or provider-administered assessment tools to assist in identifying affected patients and patient counseling strategies are reviewed.

摘要

氟班色林是美国食品药品监督管理局(FDA)批准的首个用于治疗性功能障碍,特别是性欲低下的药物。直到最近,FDA才批准了一些药物用于帮助约40%受女性性功能障碍(FSD)影响的女性。患者通常表示在讨论性健康问题时感到不自在,这表明医疗保健专业人员(HCP)迫切需要主动与患者沟通,以确定他们的担忧,并就性健康和可用的治疗方案展开讨论。在《精神疾病诊断与统计手册》第五版(DSM-5)中,概述了女性性兴趣/唤起障碍(FSIAD)的标准,其中包括最常见的性问题之一,该问题以前在其自己的类别中被定义为性欲减退障碍(HSDD)或性欲低下。HSDD是指性兴趣和/或欲望的缺乏或不足,导致严重的痛苦和人际关系困难。HCP在评估患者、提供治疗考虑信息并确保患者对该话题感到舒适方面提供了重要服务。本文概述了与FSD相关的类型和潜在原因,以及氟班色林在实践中作为一种治疗选择的作用。尽管需要在不同人群中进行更多研究,但氟班色林在临床研究中已显示出疗效,女性性功能指数(FSFI)总分和欲望领域得分有所提高,表明对性欲有好处。本文还综述了有助于识别受影响患者的常见患者或医疗人员使用的评估工具以及患者咨询策略。

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