Olesen Kasper, Jensen Troels Mygind, Diaz Lars Jorge, Møller Anne Cathrine Laustrup, Willaing Ingrid, Lyssenko Valeriya
Steno Diabetes Center A/S, Gentofte, Denmark.
Steno Diabetes Center Copenhagen, Gentofte, Denmark.
J Clin Transl Endocrinol. 2017 Feb 11;8:1-5. doi: 10.1016/j.jcte.2017.01.003. eCollection 2017 Jun.
It is a constant challenge for people with type 1 diabetes to maintain appropriate levels of HbA, blood pressure and blood lipids in order to prevent or delay deleterious effects of their illness. This study sought to investigate if Sense of Coherence (SOC) is associated with clinical risk factors in people with type 1 diabetes.
Questionnaire data, including measure of SOC, was collected from 125 patients with long duration of type 1 diabetes and linked to electronic patient records to obtain clinical measures on HbA1c, blood pressure, and blood lipids. Linear regressions and generalized additive models were applied to explore the associations between SOC and clinical biomarkers.
Mean age of the participants was 60.7 years (standard deviation = 10.0), 44.0% were men. Medium and high SOC were associated with lower levels of LDL-cholesterol (p = 0.005). This association was non-linear with medium and high levels of SOC being advantageous whereas low SOC was associated with elevated levels of LDL-cholesterol. Moreover, we observed non-significant tendencies to associations between low SOC and low HDL-cholesterol, and elevated HbA.
Findings from this study suggest that high SOC may be protective against elevated LDL-cholesterol among people with type 1 diabetes. Interventions to improve self-management among people with low SOC may prove effective to prevent deterioration of metabolic risk factors.
对于1型糖尿病患者而言，维持糖化血红蛋白（HbA）、血压和血脂在适当水平以预防或延缓疾病的有害影响一直是一项挑战。本研究旨在调查连贯感（SOC）是否与1型糖尿病患者的临床风险因素相关。
从125例病程较长的1型糖尿病患者中收集问卷数据，包括连贯感测量值，并将其与电子病历相关联，以获取糖化血红蛋白（HbA1c）、血压和血脂的临床测量值。应用线性回归和广义相加模型来探索连贯感与临床生物标志物之间的关联。
参与者的平均年龄为60.7岁（标准差 = 10.0），44.0%为男性。中等和高连贯感与较低的低密度脂蛋白胆固醇水平相关（p = 0.005）。这种关联是非线性的，中等和高连贯感具有优势，而低连贯感与较高的低密度脂蛋白胆固醇水平相关。此外，我们观察到低连贯感与低高密度脂蛋白胆固醇以及糖化血红蛋白升高之间存在不显著的关联趋势。
本研究结果表明，高连贯感可能对1型糖尿病患者的低密度脂蛋白胆固醇升高具有保护作用。改善低连贯感患者自我管理的干预措施可能被证明对预防代谢风险因素恶化有效。
