Ward David D, Andel Ross, Saunders Nichole L, Thow Megan E, Klekociuk Shannon Z, Bindoff Aidan D, Vickers James C
Wicking Dementia Research & Education Centre, University of Tasmania, Hobart, Tasmania, Australia.
School of Aging Studies, University of South Florida, Tampa, FL, USA.
Alzheimers Dement (N Y). 2017 May 15;3(3):323-331. doi: 10.1016/j.trci.2017.04.006. eCollection 2017 Sep.
Cognitive reserve (CR) and Val66Met are independently associated with the rate of cognitive decline in preclinical Alzheimer's disease. This study was designed to investigate the interactive effects of these variables on 36-month cognitive change in cognitively intact older adults.
Data for this investigation were obtained from 445 community-residing participants of the Tasmanian Healthy Brain Project, who underwent genetic screening and annual assessment of neuropsychological, health, and psychosocial function.
Our main result was that Val66Met moderated the relationship between baseline CR and change in executive function performance, in that CR-related differences in function decreased across the follow-up period in Val homozygotes, but became more pronounced in Met carriers. Similar effects were not observed within the other memory- and language-related cognitive domains.
Inheritance of Met may be associated with a detrimental influence on the relationship between CR and cognitive change in cognitively intact older adults, but this effect may be restricted to the executive function domain.
认知储备（CR）和缬氨酸66蛋氨酸（Val66Met）基因多态性与临床前阿尔茨海默病的认知衰退率独立相关。本研究旨在调查这些变量对认知功能正常的老年人36个月认知变化的交互作用。
本研究数据来自塔斯马尼亚健康大脑项目的445名社区居民参与者，他们接受了基因筛查以及神经心理学、健康和社会心理功能的年度评估。
我们的主要结果是，Val66Met基因多态性调节了基线认知储备与执行功能表现变化之间的关系，即纯合子缬氨酸（Val）携带者中与认知储备相关的功能差异在随访期间减小，而蛋氨酸（Met）携带者中则更为明显。在其他与记忆和语言相关的认知领域未观察到类似效应。
蛋氨酸（Met）的遗传可能对认知功能正常的老年人认知储备与认知变化之间的关系产生不利影响，但这种影响可能仅限于执行功能领域。
